根治性手术切除+区域淋巴结清扫术对降低结肠癌患者死亡率与减少并发症的效果  

Effect of radical resection and regional lymph node dissection on reducing mortality and complications in patients with colon cancer

作　　者：李锡丁 Li Xiding(The affiliated Wuxi No.2 hospital of Nanjing Medical University,Wuxi,Jiangsu,214002,China)

机构地区：[1]南京医科大学附属无锡第二医院,江苏无锡214002

出　　处：《齐齐哈尔医学院学报》2021年第21期1860-1864,共5页Journal of Qiqihar Medical University

摘　　要：目的探讨采取根治性手术切除+区域淋巴结清扫术对降低结肠癌患者死亡率与减少并发症的效果。方法选择2018年1月—2020年12月在本院就诊的80例结肠癌患者作为研究对象,按随机数表法分为研究组和对照组两组,每组各40例。对照组给予传统开腹术治疗,研究组给予根治性手术切除+区域淋巴结清扫术治疗。比较两组临床各项指标差异。分析术后并发症发生率、死亡率及复发率、恶性肿瘤的治疗有效率、肿瘤控制率以及血清炎症指标水平。结果研究组患者术后手术时间、术后排气时间、住院时间及术中出血量均小于对照组,差异有统计学意义(P<0.05);研究组患者术后腹腔积液、切口感染及肺部感染并发症总发生率低于对照组,差异有统计学意义(P<0.05);研究组患者术后死亡率、腹膜种植复发率、淋巴结转移复发率均低于对照组,差异有统计学意义(P<0.05);研究组患者术后肿瘤控制率、治疗有效率均高于对照组,差异有统计学意义(P<0.05);研究组患者术后超敏C反应蛋白(hs-CPR)、白介素-6(IL-6)以及肿瘤坏死因子-α(TNF-α)的指标水平均低于对照组,差异有统计学意义(P<0.05)。结论对结肠癌患者采取根治性手术切除+区域淋巴结清扫术治疗能有效改善临床各项指标,降低死亡率和并发症,改善转归,具有一定临床推广和应用价值。Objective To investigate the clinical effect of radical resection combined with regional lymph node dissection on reducing mortality and reducing complicationsfor patients with colon cancer.Methods 80 patients with colon cancer who were treated in our hospital during the periodJanuary 2018 to December 2020were selected as study objects of the study.According to the random number table grouping method,they were divided into control group(n=40)and experimental group(n=40).The control group was given traditional laparotomy treatment,and the experimental group was given radical resection combined with regional lymph node dissection.The differences of clinical indicators between the two groups were compared.The incidence of postoperative complications,mortality and recurrence rate,treatmenteffective rate of malignant tumor,tumor control rate and serum inflammation index level of the two groups were analyzed.Results Compared with the control group,the experimental group had shorter operation time,postoperative exhaust time and hospitalization time,and less intraoperative blood loss,the differences were statistically significant(P<0.05).The total incidences of postoperative peritoneal effusion,infection of incision and pulmonary infection of the experimental group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).Compared with the control group,the recurrence rate of peritoneal implantation,the recurrence rate of lymph node metastasis,and the mortality rate in the experimental group were lower,and the differences were statistically significant(P<0.05).Compared with the control group,the experimental group had higher treatment efficiency and control rate for malignant tumors,and the differences were statistically significant(P<0.05).Compared with the control group,the experimental group had lower levels of hypersensitivity C-reactive protein,interleukin-6 and tumor necrosis factorαafter treatment,and the differences were statistically significant(P<0.05).

关 键 词：结肠癌 死亡率 并发症 根治性切除 区域淋巴结清扫术 

分 类 号：R735.3[医药卫生—肿瘤]