医院机会性筛查人群人乳头瘤病毒持续感染及病毒清除情况研究  

Study on the Virus Clearance of Persistent Human Papillomavirus Infection in the Hospital Opportunistic Screening Population

作　　者：徐咏莲 舒敏 刘冰 黄秋蝉 刘运洪 谢宇 季新梅 XU Yong-lian;SHU Min;LIU Bing;HUANG Qiu-chan;LIU Yunhong;XIE Yu;JI Xin-mei(The People's Hospital of Longhua Shenzhen,Guangdong Shenzhen 518109)

机构地区：[1]深圳市龙华区人民医院,广东深圳518109

出　　处：《深圳中西医结合杂志》2021年第18期28-31,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:了解本地区医院机会性筛查人群人乳头瘤病毒(HPV)感染及持续性感染情况,为HPV在宫颈癌筛查中结果的解读和处理提供参考依据。方法:选取2018年8月至2020年8月在深圳市龙华区人民医院就诊的连续2次及以上接受宫颈HPV检查的女性为研究对象,随访观察4~24个月。分析HPV的感染情况,同时应用Kaplan-MeieR生存分析估计HPV病毒清除时间及病毒消退曲线。结果:HPV人群感染率为17.41%,高危型为15.39%,明显高于疑高危型的1.94%和低危型为6.53%。感染人群中HPV总的持续感染率为27.0%,低危型、疑高危型、高危型持续感染率分别为26.2%,19.0%和28.4%。人群感染率排名最前的HPV型别:高危组分别是HPV52/16/58,低危型别是HPV44/61/42。感染人群中最常见的HPV持续性感染型别:高危型别是HPV59(71.1%)、HPV56(43.3%)、HPV16(38.1%)、HPV58(33.4%)和HPV33(28.2%);低危型别是HPV42(45.1%)、HPV44(34.8%)、HPV40(30.3%)、HPV11(28.6%)、HPV6(17.8%)。结论:医院机会筛查人群各亚型HPV感染的人群感染率和持续性感染率不同。最常见的高危组HPV持续性感染的型别是HPV59/56/16/58/33;低危组HPV持续性感染的型别是HPV42/44/40/11/6。Objective To investigate the infection and distribution characteristics of human papillomavirus(HPV)in Longhua district of Shenzhen from hospital opportunistic screening,to obtain the persistent and clearance infection of HPV,thus to provide scientific reference basis for the interpretation and treatment of human papillomavirus results in clinical cervical cancer screening.Methods Female patients received more than 2 times of cervical HPV tests in People's Hospital of Longhua Shenzhen from August 2018 to August 2020 were followed up for 4–24 months.Kaplan–Meier survival analysis was performed to estimate the time of HPV clearance.Results The HPV infections rate was 17.41%.The HPV infection rate of high-risk types was 15.39%which was significantly higher than that of suspected high risk types 1.94%and low–risk types 6.53%.The overall persistent infection rate of HPV in infected population was 27%,and the rate of low–risk,suspected high–risk types and high–risk types persistent infection was 26.2%,19.0%and 28.4%,respectively.HPV52(4.16%),HPV16(2.35%),HPV58(2.19%),HPV51(1.36%),HPV53(0.97%)were top five genotypes among the high risk types,and HPV42(45.1%),HPV44(34.8%),HPV40(30.3%),HPV11(28.6%)and HPV6(17.8%)were top five genotypes among the low-risk types.Conclusion There were difference between infection rates and persistent infection rates in populations from hospital opportunistic screening.The most common type of HPV persistent infection is HPV59/56/16/58/33.The type of HPV persistent infection in the low-risk group is HPV42/44/40/11/6.

关 键 词：人乳头瘤病毒 宫颈癌筛查 持续感染 基因型 

分 类 号：R73[医药卫生—肿瘤]