基于GC-IMS气味检测辨识侧柏叶炒炭程度研究  

Primary study on identification of carbonizing degree of Platycladi Cacumen based on odor detection by GC-IMS

作　　者：石典花[1,2] 戴衍朋[1] 卢琪 孙立立[1] 张学兰[2] 张军[1] SHI Dian-hua;DAI Yan-peng;LU Qi;SUN Li-li;ZHANG Xue-lan;ZHANG Jun(Shandong Academy of Chinese Medicine,Jinan 250014,China;Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东省中医药研究院,山东济南250014 [2]山东中医药大学,山东济南250355

出　　处：《中草药》2021年第21期6510-6517,共8页Chinese Traditional and Herbal Drugs

基　　金：山东省中医药高层次人才培育项目(2021);全国中药特色技术传承人才培训项目(2019);科技基础性工作专项分项目(2014FY111100);齐鲁医派中医学术流派传承项目(中药蜜制与制炭特色技术,齐鲁道地药材炮制存性特色技术);山东省中医药科技发展计划(2015-173);山东省中医药科技发展计划(2017-130);山东省职业教育技艺技能传承创新平台建设计划。

摘　　要：目的从气味变化角度对侧柏叶炒炭程度进行辨识。方法采用气相色谱-离子迁移谱法(gas chromatography-ion mobility spectrometry,GC-IMS)对侧柏叶和不同炒制程度侧柏炭的气味进行检测,采用直观、聚类、指纹图谱法对其进行比较和定性分析。结果通过气味分析可明显区分开侧柏叶及不同炒制程度侧柏炭,5-甲基糠醛、2-庚醇和2-乙酰呋喃可作为侧柏叶炒适中炭的标志物。结论侧柏叶炒炭后气味发生了明显的变化,且与炮制程度相关,研究结果可为辨识炭药炮制程度研究提供了一定的思路。Objective To identify the carbonizing degree of Platycladi Cacumen(PC)from the perspective of odor changes.Methods The odor of PC and Platycladi Cacumen Carbonisata(PCC)of different carbonizing degree were detected by gas chromatography-ion mobility spectrometry(GC-IMS),which is compared and qualitatively analyzed by intuitive,clustering and fingerprinting methods.Results It was clearly to distinguish PC and PCC of different carbonizing degree by odor analysis.5-Methylfurfural,2-heptanol and 2-acetylfuran can be used as markers of moderate PCC.Conclusion The odor of PC changed significantly after being carbonized and it is related to processing degree.The research results can provide a certain idea for the research on identifying the processing degree of charcoal medicine.

关 键 词：侧柏叶 炒炭 侧柏炭 气相色谱-离子迁移谱 气味 指纹图谱 5-甲基糠醛 2-庚醇 2-乙酰呋喃 炭药 炮制 

分 类 号：R283.1[医药卫生—中药学]