Ⅰ型子宫内膜癌中L1-CAM的表达与临床病理特征及预后的关系  

The expression of L1-CAM in typeⅠendometrial carcinoma and its relationship with clinicopathological characteristics and prognosis

作　　者：张媛[1] 张競[1] 刘静[1] 刘梦君 ZHANG Yuan;ZHANG Jing;LIU Jing;LIU Mengjun(Department of Gynecologic Oncology,First Affiliated Hospital of Bengbu Medical College,Bengbu,233004)

机构地区：[1]蚌埠医学院第一附属医院肿瘤妇科,安徽蚌埠233004

出　　处：《包头医学院学报》2021年第11期10-14,共5页Journal of Baotou Medical College

基　　金：蚌埠医学院自然科学基金项目(2018BYKY1887)。

摘　　要：目的:探讨Ⅰ型子宫内膜癌组织中L1细胞黏附分子(L1-CAM)的表达情况及其与患者临床病理特征和预后的关系,为子宫内膜癌患者的预后评估提供依据。方法:应用免疫组化方法检测2011年1月-2013年4月收治的90例子宫内膜癌和90例正常子宫内膜组织中L1-CAM的表达情况,分析其与子宫内膜癌患者临床病理特征及预后的关系。结果:子宫内膜癌组织中L1-CAM阳性表达率为48.9%(44/90),明显高于正常子宫内膜组织中的13.3%(12/90),差异有统计学意义(P<0.05)。L1-CAM表达与患者年龄、绝经情况、FIGO分期、肿瘤大小及术后辅助治疗无明显相关(P>0.05),与细胞分化、肌层浸润深度、淋巴结转移呈正相关(P<0.05)。子宫内膜癌患者5年存活率与患者年龄、绝经情况、FIGO分期、肿瘤大小及术后辅助治疗无明显相关(P>0.05),与细胞分化、肌层浸润深度、淋巴结转移、L1-CAM阳性表达呈正相关(P<0.05)。多因素Cox比例风险回归分析结果显示,细胞分化、肌层浸润深度、L1-CAM表达是影响子宫内膜癌患者的独立预后因素。结论:L1-CAM的表达与子宫内膜癌的恶性程度有关,通过检测L1-CAM表达可能对子宫内膜癌患者的预后判断提供一定的指导价值。Objective:To explore the expression of L1 cell adhesion molecule(L1-CAM)in typeⅠendometrial carcinoma and its relationship with clinicopathological characteristics and prognosis,provide a theoretical basis for prognosis evaluation.Methods:Immunohistochemical method was used to detect the expression of L1-CAM in 90 cases of endometrial carcinoma and 90 cases of normal endometrium.The relationship between the expression of L1-CAM and the clinicopathological factors and prognosis of patients with endometrial carcinoma was analyzed.Results:The positive expression rate of L1-CAM in endometrial carcinoma tissues was 48.9%(44/90),which was significantly higher than that in normal endometrium13.3%(12/90),and the difference was of statistical significance(P<0.05).L1-CAM expression was not significantly correlated with age,menopause or not,clinical stage,tumor size of endometrial carcinoma and postoperative adjuvant therapy(P>0.05).L1-CAM expression was correlated with carcinoma cells,depth of myometrial invasion and lymph node metastasis(P<0.05).Five year survival rate of patients with endometrial carcinoma was not significantly correlated with age,menopause or not,clinical stage,tumor size of endometrial carcinoma and postoperative adjuvant therapy(P>0.05),but was positively correlated with carcinoma cells,depth of myometrial invasion,lymph node metastasis and expression of L1-CAM(P<0.05).Multivariate Cox proportional hazard regression revealed that,carcinoma cells,depth of myometrial invasion and expression of L1-CAM were indepentdent influencing factors of prognosis of endometrial carcinoma patients.Conclusion:The expression of L1-CAM is related to malignant degree,detecting the expression of L1-CAM can be hoped to provide a new theoretical basis for prognosis evaluation of endometrial carcinoma.

关 键 词：子宫内膜癌 L1细胞黏附分子 病理特征 预后 

分 类 号：R73[医药卫生—肿瘤]