重度抑郁症啮齿类动物模型研究进展  

Research progress in rodent modeling of major depressive disorder

作　　者：周珺 许向阳 张长青 罗欢 张玲 蒋钰 胡一桥[1] ZHOU Jun;XU Xiang-yang;ZHANG Chang-qing;LUO Huan;ZHANG Ling;JIANG Yu;HU Yi-qiao(School of Medicine,Nanjing University,Nanjing 210093,China;Jiangsu Nhwa Pharmaceutical Co.,Ltd,Xuzhou Jiangsu 221000,China)

机构地区：[1]南京大学医学院,江苏南京210093 [2]江苏恩华药业股份有限公司,江苏徐州221000

出　　处：《中国药理学通报》2021年第12期1648-1653,共6页Chinese Pharmacological Bulletin

基　　金：国家“重大新药创制”科技重大专项(No 2018ZX09711002);江苏省中枢神经药物研究重点实验室资助项目(No BM2019004)。

摘　　要：重度抑郁症(major depressive disorder,MDD)致残率高,自杀风险大。基于单胺假说的传统抗抑郁药物疗效有限,为解决临床需求,研究者们积极开发多种不同机制的动物模型。近年来,伴随着基因工程和分子生物学技术的快速发展,重度抑郁症动物模型研究也有了不小的进展,该文对较为常用的啮齿类动物模型进行总结,对其原理和制备方法、表型特征、模型有效性(对临床MDD的模拟性)以及其优缺点进行综述,旨在为研究者选择合适的动物模型探索MDD的发病机制,进行抗MDD新药研发。Major depressive disorder(MDD)has a high disability rate and a high risk of suicide.Due to the limited efficacy of traditional antidepressants,researchers have actively developed animal models with different mechanisms to meet the clinical needs.The principle and preparation methods,phenotypic characteristics,model validity(simulating clinical MDD)and their advantages and disadvantages of different models have been reviewed in this article.It is helpful for researchers to explore the pathogenesis of MDD and to select appropriate animal models in the development of new anti-MDD drugs.

关 键 词：重度抑郁症 啮齿类 抗抑郁药物 动物模型 表型特征 模型有效性 应激 

分 类 号：R-332[医药卫生] R363-332