比格犬下颌骨层片状与线性骨折愈合进程中生物力学分析  

Biomechanical assessment of healing process of lamellae and linear fractures of beagle mandibular layers

作　　者：邵静宇 陈俊文 李军[1] 徐前[1] SHAO Jingyu;CHEN Junwen;LI Jun;XU Qian(Department of Oral and Maxillofacial Surgery,People's Hospital of Xinjian Uygur Autonomous Region,Urumqi 830011,China;Department of Stomatology,Hubei Tianmen First People's Hospital,Tianmen Hubei 431700,China)

机构地区：[1]新疆维吾尔自治区人民医院口腔颌面外科,乌鲁木齐830001 [2]湖北省天门市第一人民医院口腔科,湖北天门431700

出　　处：《新疆医科大学学报》2021年第12期1317-1322,共6页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区自然科学基金(2018D01C099)。

摘　　要：目的通过建立下颌骨体部骨折坚固内固定动物模型,分析下颌骨骨折愈合过程中的影像学、组织学变化及愈合过程中的生物力学评估。方法成年健康比格犬18只,按比格犬登记顺序编号,将偶数分为线性组(下颌骨体部线性骨折),奇数分为层片组(下颌骨体部层片状骨折),每组9只。线性组于犬下颌骨体部行线性截骨建立纵向线性骨折,层片组于犬下颌骨体部行层片状截骨建立长度约2.0 cm、角度约25°的下颌骨层片骨折。两种不同类型骨折用钛板固定后2周、1个月、3个月拆除钛板,通过影像学、组织学及生物力学对不同时间点的样本愈合情况进行观察与评估。结果根据影像学图片比较,层片组愈合速度整体上较线性组快。HE、Masson染色结果显示,两组在愈合形式上一致,层片组成骨细胞、纤维等组织较线性组丰富。术后2周,两组在刚度、最大载荷、断裂能比较差异均无统计学意义(P>0.05);术后1个月,层片组最大载荷、断裂能高于线性组,差异具有统计学意义(P<0.05);术后3个月,层片组最大载荷、刚度高于线性组,差异具有统计学意义(P<0.05)。层片组骨折愈合后的生物力学结果总体较线性组好。两组术后1个月、3个月生物力学比较差异具有统计学意义(P<0.05),层片组骨折愈合后力学性能优于线性组。结论下颌骨体部层片状骨折所受生物力学更有利于骨折愈合,可为临床手术方式、治疗方案及干预措施提供理论依据。Objective To analyze the imaging and histological changes during the process of mandibular fracture healing and biomechanical assessment,the research established an animal model of mandibular body lamina and linear fracture with sturdy internal fixation.Methods 18 adult healthy Beagles were numbered in Beagle registration order,with even numbers divided into linear groups(linear fractures of the body of the mandible)and odd numbers into lamellar groups(lamellar fractures of the body of the mandible),with nine dogs in each group.In the linear group,a longitudinal linear fracture was created by a linear osteotomy of the body of the mandible,and in the laminar group,a laminar fracture of the mandible was created by a laminar osteotomy of the body of the mandible of approximately 2.0 cm in length with an angle of approximately 25°.2 weeks,1 month and 3 months after fixation with a titanium plate,the plates were removed,and the healed bone samples were observed and evaluated by imaging,histology and biomechanics at different times.Results Based on comparison of the imaging pictures,the lamellar group healed faster overall than the linear group.HE and Masson staining,the lamellar and linear groups were consistent in the form of healing,and the lamellar group was richer in bone cells,fibres and other tissues than the linear group.2 weeks after operation,there was no statistical significance in stiffness,maximum load,and fracture energy(P?0.05)between the lamellar and linear fracture groups.1 month after operation,the differences in maximum load and fracture energy were statistically significant(P<0.05)in the lamellar group compared to the linear group.3 months after operation,the differences in maximum load and stiffness were statistically significant(P?0.05)in the lamellar group compared to the linear group.The biomechanics of the laminar fracture after the healing was generally better than the linear one.The difference in biomechanics between the two groups at 1 and 3 months postoperatively were statistically signifi

关 键 词：下颌骨骨折 层片状骨折 生物力学 

分 类 号：R782.4[医药卫生—口腔医学]