改良ECF方案联合射频热疗治疗胃癌腹膜转移的临床疗效  

Clinical effect of modified ECF regimen combined with radiofrequency hyperthermia in treatment of gastric cancer peritoneal metastasis

作　　者：李成彪 雷金花 王玉珮 胡芳霞 LI Cheng-biao;LEI Jin-hua;WANG Yu-pei;HU Fang-xia(Department of Oncology,People’s Hospital of Wuwei City,Wuwei GANSU 733000,China)

机构地区：[1]武威市人民医院肿瘤内科,甘肃武威733000

出　　处：《中国新药与临床杂志》2021年第11期776-779,共4页Chinese Journal of New Drugs and Clinical Remedies

基　　金：武威市市列科技计划项目(WW1902020)。

摘　　要：目的评价改良ECF(m ECF)方案联合射频热疗治疗胃癌腹膜转移(GCPM)的有效性及安全性。方法纳入GCPM患者60例,随机分为治疗组和对照组,每组30例。对照组采用mECF方案(表柔比星50 mg·m^(-2),静脉给药,第1日+顺铂60 mg·m^(-2),腹腔灌注,第1日+卡培他滨1 000 mg·m^(-2) po bid,第1~14日)化疗4个周期,21 d为一个治疗周期。治疗组在mECF方案基础上给予腹部射频热疗。治疗4个周期后评价近期疗效,通过卡氏功能评分(KPS)和疼痛数值量表(NRS)评价临床获益情况,观察不良反应发生情况。结果对照组和治疗组的客观缓解率(ORR)分别为27%(8/30)和53%(16/30),有显著差异(P <0.05)。治疗后治疗组KPS高于对照组[(73.5±8.6)分vs.(69.0±7.2)分)],NRS评分低于对照组[(2.0±1.1)分vs.(3.4±1.8)分],均有显著差异(P <0.05)。对照组和治疗组Ⅲ~Ⅳ级白细胞减少、恶心呕吐发生率分别为27%(8/30)、23%(7/30)和20%(6/30)、20%(6/30),2组相比均无显著差异(P> 0.05)。结论 mECF方案化疗联合射频热疗治疗GCPM疗效优于单纯mECF方案化疗,且Ⅲ~Ⅳ级不良反应无明显增加。AIM To evaluate the effectiveness and safety of modified ECF(mECF) regimen combined with radiofrequency hyperthermia in the treatment of gastric cancer peritoneal metastasis(GCPM).METHODS Sixty patients with GCPM were enrolled and randomly divided into treatment group and control group,with 30 cases in each group.The control group was treated with mECF regimen(epirubicin 50 mg·m^(-2),intravenous administration,on the first day + cisplatin 60 mg·m^(-2),intraperitoneal infusion,on the first day + capecitabine 1 000 mg·m^(-2) po bid,1 st to 14 th days)chemotherapy for 4 cycles,repeated every 21 days as a treatment cycle.The treatment group was given abdominal radiofrequency hyperthermia on the basis of mECF regimen.The short-term efficacy was evaluated after 4 cycles of treatment,and the clinical benefit was evaluated by the Karnofsky performance score(KPS) and the numerical rating scale(NRS) of pain,and the occurrence of adverse reactions was observed.RESULTS The objective response rate(ORR) of the control group and the treatment group were 27%(8/30) and 53%(16/30) respectively,with significantly different(P < 0.05).After treatment,the KPS of the treatment group(73.5±8.6) was higher than that of the control group(69.0±7.2,P < 0.05),and the NRS score(2.0±1.1) was lower than the control group(3.4±1.8,P < 0.05).There was no significant difference the incidence of grade-leukopenia and nausea and vomiting between the control group and treatment group(27%(8/30) vs.20%(6/30) and 23%(7/30) vs.20%(6/30),P > 0.05).CONCLUSION The efficacy of mECF regimen chemotherapy combined with radiofrequency hyperthermia in the treatment of GCPM is better than mECF regimen alone,and there is no significant increase in grade Ⅲ-Ⅳ adverse reactions.

关 键 词：胃肿瘤 射频疗法 药物疗法 联合 

分 类 号：R735.2[医药卫生—肿瘤]