β-环糊精衍生物对5-氟尿嘧啶包合和增溶研究  

Utilization ofβ-cyclodextrin Derivatives as Solubilizer to 5-fluorouracil

作　　者：甘永江 张贝 张毅民[2] 凌善锋 GAN Yong-jian;ZHANG Bei;ZHANG Yi-min;LING Shan-feng(Shanwei Vocational and Technical College,Guangdong Shanwei 516600;Key Laboratory for Green Chemical Technology of State Education Ministry,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China)

机构地区：[1]汕尾职业技术学院,广东汕尾516600 [2]天津大学,绿色合成与转化教育部重点实验室,化工学院,天津300072

出　　处：《广州化工》2021年第23期63-64,86,共3页GuangZhou Chemical Industry

基　　金：汕尾职业技术学院科研启动经费项目(SKQD2012B-23)。

摘　　要：采用相溶解度法,测定5-氟尿嘧啶在不同浓度的β-环糊精、甲基化β-环糊精、乙基化β-环糊精和羟丙基-β-环糊精溶解度,绘制相溶解度曲线,计算了包结稳定常数、包结率和增溶倍数,比较了β-环糊精、甲基化β-环糊精和乙基化β-环糊精对5-氟尿嘧啶的增溶作用。结果表明,包结常数和包结率随着β-环糊精衍生物的取代基团链长增加而增加,β-环糊精及其衍生物对5-氟尿嘧啶均有增溶作用。By measuring the solubility of 5-fluorouracil in differentβ-cyclodextrin,ethyl-β-cyclodextrin hydroxypropyl-β-cyclodextrinand ethyl-β-cyclodextrin concentration,the stability constants,the complexation efficiencies and the most solubility multiples were calculated,the phase solubility graphs were described,and solubilization effects of 5-fluorouracil in differentβ-cyclodextrin,methyl-β-cyclodextrin and ethyl-β-cyclodextrin were compared.The results showed that the stability constants and the complexation efficiencies were enhanced with increase of the degree of substitution and the length of substituent group,β-cyclodextrinand its derivatives can increase the solubility of 5-fluorouracil.

关 键 词：Β-环糊精 衍生物 5-氟尿嘧啶 增溶 

分 类 号：O657.3[理学—分析化学]