丹参多酚酸治疗恢复期前循环中度脑梗死的临床效果  

Clinical Effect of Salvianolic Acid in the Treatment of Moderate Cerebral Infarction in Recovery Anterior Circulation

作　　者：夏建华 尹俊峰 焦慧娟 胡伟盛 刘俊平 XIA Jianhua;YIN Junfeng;JIAO Huijuan;HU Weisheng;LIU Junping(Department 1 of Neurology,Zhumadian Central Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市中心医院神经内一科,河南驻马店463000

出　　处：《河南医学研究》2021年第35期6635-6637,共3页Henan Medical Research

基　　金：河南省医学科技攻关计划项目(2018020729)。

摘　　要：目的观察丹参多酚酸治疗恢复期前循环中度脑梗死的效果。方法选取驻马店市中心医院2018年12月至2020年1月收治的120例恢复期前循环脑梗死患者,应用随机数表法分为对照组和观察组,每组60例。对照组接受抗血小板聚集、降脂、康复等治疗,观察组在对照组基础上加用丹参多酚酸静脉滴注,两组均治疗14 d。比较两组患者治疗前后日常生活能力评分、美国国立卫生研究院卒中量表(NIHSS)评分、治疗效果和不良反应。结果两组均未见明显不良反应。治疗前两组患者的日常生活能力和NIHSS评分比较,差异无统计学意义(P>0.05);治疗后两组NIHSS评分均低于治疗前,且观察组较对照组高(P<0.05);治疗后两组日常生活能力评分均较治疗前高,且观察组较对照组高(P<0.05)。观察组有效率较对照组高(P<0.05)。结论丹参多酚酸治疗恢复期前循环中度脑梗死是安全的,且效果显著。Objective To observe the efficacy of salvianolic acid in the treatment of moderate cerebral infarction in recovery anterior circulation.Methods A total of 120 patients with convalescent moderate anterior circulation infarction in Zhumadian Central Hospital from December 2018 to January 2020 were selected.The patients were divided into control group and observation group using random number table,with 60 cases in each group.The control group received anti-platelet aggregation,lipids lowering,rehabilitation and other treatments.The observation group additionally received salvianolic acid.Both groups were treated for 14 days.The daily living ability score,National Institutes of Health stroke scale(NIHSS)score,treatment effect and adverse reactions were compared between two groups before and after treatment.Results There were no obvious adverse reactions in both groups.There were no statistical differences in daily living ability score and NIHSS score between the two groups before treatment(P>0.05).After treatment,NIHSS scores of the two groups were lower than those before treatment,and the observation group was higher than the control group(P<0.05).After treatment,the daily living ability scores in both groups were higher than those before treatment,and the observation group was higher than the control group(P<0.05).The effective rate in the control group were higher than that in the control group(P<0.05).Conclusion Salvianolic Acid is safe and effective in the treatment of moderate cerebral infarction in recovery anterior circulation.

关 键 词：丹参多酚酸 前循环脑梗死 疗效 

分 类 号：R743[医药卫生—神经病学与精神病学]