经皮穴位电刺激联合旋金降逆方治疗反流性食管炎肝胃郁热证的研究  

Research on transcutaneous acupoint electrical stimulation combined with Xuanjin Jiangni Decoction in the treatment of reflux esophagitis of type of heat stagnation of liver and stomach

作　　者：尚莹莹[1] 王文娟 张莲[1] 郭召平[1] 吴晓华[1] 杨伟[1] 梁春耕 肖定洪 SHANG Yingying;WANG Wenjuan;ZHANG Lian;GUO Zhaoping;WU Xiaohua;YANG Wei;LIANG Chungeng;XIAO Dinghong(Shanghai Jiading District Hospital of Traditional Chinese Medicine, Shanghai Jiading 201800, China)

机构地区：[1]上海市嘉定区中医医院,上海201800

出　　处：《现代中西医结合杂志》2021年第34期3769-3773,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：嘉定区科委立项项目(JDKW-2016-w24);上海市“杏林新星”计划项目(ZY3-RCPY-2-2060);嘉定区中医工作室建设项目(ZYGZS-06)。

摘　　要：目的评价经皮穴位电刺激联合旋金降逆方治疗反流性食管炎肝胃郁热证的临床疗效。方法选择2017年1月—2019年9月在上海市嘉定区中医医院诊治的反流性食管炎患者140例,采用随机分组方法将患者分为4组,每组35例。穴位电刺激联合旋金降逆方组给予经皮穴位电刺激及旋金降逆方口服,穴位电刺激模拟联合旋金降逆方组给予经皮穴位电刺激模拟治疗及旋金降逆方口服,旋金降逆方组给予旋金降逆方口服,奥美拉唑组给予奥美拉唑口服,4组均治疗8周。比较4组治疗后临床症状(临床症状积分和临床症状疗效)、血浆胃肠激素[胃动素(MTL)、生长激素释放肽(Ghrelin)、胃泌素(GAS)]水平和食管黏膜炎症疗效。结果治疗8周后,4组患者临床症状积分均较治疗前明显降低(P均<0.05),治疗后各组间比较差异均无统计学意义(P均>0.05);穴位电刺激联合旋金降逆方组临床症状总有效率明显高于旋金降逆方组和奥美拉唑组(P均<0.05),与穴位电刺激模拟联合旋金降逆方组比较差异无统计学意义(P>0.05)。治疗8周后,4组血浆Ghrelin水平和穴位电刺激联合旋金降逆方组、穴位电刺激模拟联合旋金降逆方组、旋金降逆方组血浆MTL、GAS水平均明显高于治疗前(P均<0.05),奥美拉唑组血浆MTL、GAS水平与治疗前比较差异均无统计学意义(P均>0.05);穴位电刺激联合旋金降逆方组血浆MTL水平明显高于旋金降逆方组和奥美拉唑组(P均<0.05),血浆Ghrelin水平明显高于其他3组(P均<0.05);各组间血浆GAS水平和食管黏膜炎症总有效率比较差异均无统计学意义(P均>0.05)。结论经皮穴位电刺激联合旋金降逆方能够明显减轻反流性食管炎肝胃郁热证患者的临床症状,调节胃肠激素水平,改善内镜下食管黏膜炎症。Objective It is to evaluate the clinical efficacy of transcutaneous acupoint electrical stimulation combined with Xuanjin Jiangni Decoction in the treatment of reflux esophagitis of type of heat stagnation of liver and stomach.Methods A total of 140 reflux esophagitis patients who were diagnosed and treated in Jiading District Hospital of Traditional Chinese Medicine from January 2017 to September 2019 were selected and divided into 4 groups by randomization method,with 35 cases in each group.Acupoint electrical stimulation combined with Xuanjin Jiangni Decoction group was given transcutaneous acupoint electrical stimulation and Xuanjin Jiangni Decoction orally,acupoint electrical stimulation simulation combined with Xuanjin Jiangni Decoction group was given transcutaneous acupoint electrical stimulation simulation therapy and Xuanjin Jiangni Decoction orally,Xuanjin Jiangni Decoction group was given Xuanjin Jiangni Decoction orally,omeprazole group was given omeprazole orally,all the 4 groups were treated for 8 weeks.The clinical symptoms(clinical symptom score and clinical symptom efficacy),the levels of plasma gastrointestinal hormone[motilin(MTL),growth hormone releasing peptide(Ghrelin),gastrin(GAS)]and the efficacy of esophageal mucosal inflammation after treatment in the 4 groups were compared.Results After 8 weeks of treatment,the clinical symptom scores of the 4 groups were significantly lower than those before treatment(all P<0.05),and there was no significant difference between the groups after treatment(all P>0.05);the total effective rate of clinical symptoms in the acupoint electrical stimulation combined with Xuanjin Jiangni group was significantly higher than that of the Xuanjin Jiangni Decoction group and the omeprazole group(P<0.05),and there was no significant difference compared with the acupoint electrical stimulation simulation combined with Xuanjin Jiangni Decoction group(P>0.05).After 8 weeks of treatment,the plasma levels of Ghrelin of the 4 groups,and plasma levels of MTL and GAS of acup

关 键 词：反流性食管炎 经皮穴位电刺激 旋金降逆方 足三里 肝胃郁热证 

分 类 号：R571[医药卫生—消化系统]