幽门螺旋杆菌感染合并非酒精性脂肪性肝病患者血清胎球蛋白A水平变化及影响因素分析  

The change of serum fetuin A level and its influencing factors in patients with Helicobacter pylori infection complicated with nonalcoholic fatty liver disease

作　　者：罗超[1] 廖江涛 LUO Chao;LIAO Jiangtao(Department of Gastroenterology,the First Affiliated Hospital of Hunan Normal University,Changsha,Hunan 410000,China)

机构地区：[1]湖南师范大学附属第一医院消化内科,湖南长沙410000

出　　处：《检验医学与临床》2021年第24期3517-3520,共4页Laboratory Medicine and Clinic

基　　金：湖南省自然科学基金项目(2017SK50523)。

摘　　要：目的观察幽门螺旋杆菌(Hp)感染合并非酒精性脂肪性肝病(NAFLD)患者的血清胎球蛋白A(Fet A)的水平,并分析其影响因素。方法选取2020年1-6月在该院健康体检中心确诊为Hp感染合并NAFLD的患者82例作为Hp感染+NAFLD组,单纯NAFLD患者96例作为NAFLD组。采用酶联免疫吸附试验(ELISA)检测纳入研究者的血清Fet A水平。采用Pearson相关分析Fet A水平与血脂、胰岛素抵抗指数(HOMA-IR)等指标的相关性,多元线性回归分析Fet A的影响因素,Logistic回归分析Hp感染合并NAFLD的危险因素。结果Hp感染+NAFLD组三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、空腹胰岛素(FINS)、HOMA-IR、Fet A均大于或高于NAFLD组,高密度脂蛋白胆固醇(HDL-C)水平低于NAFLD组,差异有统计学意义(P<0.05)。血清Fet A水平与TG、LDL-C和HOMA-IR分别呈正相关(r=0.275、0.481、0.481,P<0.05),与HDL-C呈负相关(r=-0.421,P<0.05)。LDL-C、HOMA-IR、HDL-C是血清Fet A水平的影响因素(P<0.05)。在TG、HDL-C、HOMA-IR不变的情况下,Fet A是Hp感染合并NAFLD的独立危险因素(OR值为1.052,P<0.05)。结论Hp感染合并NAFLD患者Fet A水平升高,Fet A是Hp感染合并NAFLD的危险因素。Objective To observe the level of fetuin A(Fet A)in patients with Helicobacter pylori(Hp)infection complicated with nonalcoholic fatty liver disease(NAFLD)and analyze its influencing factors.Methods A total of 82 patients with Hp infection complicated with NAFLD(Hp infection+NAFLD group)and 96 patients with simple NAFLD(NAFLD group)were enrolled in the study from January to June 2020 in the health examination center of the hospital.The serum Fet A in each patient was detected by using enzyme-linked immunosorbent assay(ELISA).The correlations between Fet A and blood lipid indicators,insulin resistance index(HOMA-IR)and other indicators were analyzed by Pearson correlation,the influencing factors of Fet A were analyzed by multiple linear regression,and the risk factors of Hp infection complicated with NAFLD were analyzed by Logistic regression.Results The levels of triglyceride(TG),LDL-C,fasting plasma glucose(FPG),fasting insulin(FINS),HOMA-IR and Fet A in Hp infection+NAFLD group were significantly higher than those in NAFLD group,while HDL-C was significantly lower than that in NAFLD group(P<0.05).Serum Fet A was positively correlated with TG,LDL-C and HOMA-IR(r=0.275,0.481,0.481,P<0.05),and negatively correlated with HDL-C(r=-0.421,P<0.05).LDL-C,HOMA-IR and HDL-C were the influencing factors of serum Fet A(P<0.05).Fet A was an independent risk factor for Hp infection complicated with NAFLD when TG,HDL-C and HOMA-IR were kept unchanged(OR=1.052,P<0.05).Conclusion Fet A levels increase in patients with Hp infection complicated with NAFLD and,and Fet A is a risk factor for Hp infection complicated with NAFLD.

关 键 词：幽门螺旋杆菌感染 非酒精性脂肪性肝病 胎球蛋白A 

分 类 号：R573[医药卫生—消化系统] R575[医药卫生—内科学]