注射用胸腺肽α1联合NP方案化疗对年龄>60岁肺癌患者CD4^(+)/CD8^(+)比值及血清miR-203、miR-197表达的影响  

Effects of thymopeptideα1 for injection combined with NP chemotherapy on CD4^(+)/CD8^(+)ratio and miR-203 and miR-197 expression in serum of lung cancer patients aged>60 years

作　　者：王伟 Wang Wei(The People's Hospital of Yancheng,Luohe 462300,Henan,China)

机构地区：[1]漯河市郾城区人民医院内科,河南漯河462300

出　　处：《四川生理科学杂志》2021年第9期1493-1496,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:探究注射用胸腺肽α1联合NP方案化疗对年龄>60岁肺癌患者CD4^(+)/CD8^(+)比值及血清miR-203、miR-197表达的影响。方法:选取我院2017年2月~2018年10月>60岁肺癌患者106例,根据治疗方案不同分组,各53例。对照组采用NP方案化疗,观察组于对照组基础上加用注射用胸腺肽α1。对比两组疗效及治疗前后免疫功能指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、血清肿瘤标志物(神经特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)、癌胚抗原(CEA)、血管内皮生长因子(VEGF)、细胞质胸苷激酶1(TK1))和miR-203、miR-197水平。结果:观察组总缓解率高于对照组(P<0.05);治疗后观察组血清CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于对照组(P<0.05)。治疗后观察组血清CEA、Cyfra21-1、NSE水平低于对照组(P<0.05)。治疗后观察组血清VEGF、TK1水平低于对照组(P<0.05)。治疗后观察组血清miR-203、miR-197水平低于对照组(P<0.05)。结论:注射用胸腺肽α1联合NP方案化疗治疗年龄>60岁肺癌患者,可改善免疫功能,调节血清miR-203、miR-197、VEGF、TK1表达,降低血清肿瘤标志物水平,效果显著。Objective:To investigate the effects of thymopeptideα1 for injection combined with NP chemotherapy on the ratio of CD4^(+)/CD8^(+)and the expression of miR-203 and miR-197 in serum of lung cancer patients aged older than 60 years.Methods:106 patients with lung cancer aged older 60 years were selected from our hospital from February 2017 to October 2018.According to different treatment regimens,there were 53 patients in each group.The control group was treated with NP chemotherapy,and the observation group was additively treated with thymosinα1 for injection.The curative effect and immune function indexes(CD3^(+),CD4^(+),CD4^(+)/CD8^(+)),serum tumor markers(neurospecific enolase(NSE),cytokeratin 19 fragment(CYFRA21-1),carcinoembryonic antigen(CEA)),vascular endothelial growth factor(VEGF),cytoplasmic thymidine kinase 1(TK)and miR-203 and miR-197 before and after treatment were compared.Results:The total remission rate of observation group was higher than that of control group(P<0.05).After treatment,the levels of serum CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in observation group were higher than those in control group(P<0.05).After treatment,the levels of serum CEA,CYFRA21-1 and NSE in observation group were lower than those in control group(P<0.05).After treatment,the levels of serum VEGF and TK1 in observation group were lower than those in control group(P<0.05).After treatment,the levels of miR-203 and miR-197 in the observation group were lower than those in the control group(P<0.05).Conclusion:Thymopeptideα1 for injection combined with NP chemotherapy can improve the immune function,regulate the expression of miR-203,miR-197,VEGF and TK1 in serum,and reduce the level of serum tumor markers,with significant effect.

关 键 词：注射用胸腺肽α1 NP方案 肺癌 免疫功能 

分 类 号：R73[医药卫生—肿瘤]