复方紫海胆黄油软胶囊制备工艺的研究  

The optimized softgels manufacturing technology of sea urchin Heliocidaris crassispina gonad oil complex

作　　者：潘南[1] 邓玉凤 徐清云 段义凡 周逢芳 郑昇阳 刘智禹[1] PAN Nan;DENG Yufeng;XU Qingyun;DUAN Yifan;ZHOU Fengfang;ZHENG Shengyang;LIU Zhiyu(National Research and Development Center for Marine Fish Processing,Key Laboratory of Cultivation and High-value Utilization of Marine Organisms in Fujian Province,Fisheries Research Institute of Fujian,Xiamen 361013,China;School of Life Sciences,Ningde Normal University,Ningde 352100,China;Xiamen Institute of Software Technology,Xiamen 361024,China)

机构地区：[1]福建省水产研究所,国家海水鱼类加工技术研发分中心,福建省海洋生物增养殖与高值化利用重点实验室,福建厦门361013 [2]宁德师范学院生命科学学院,福建宁德352100 [3]厦门软件职业技术学院软件工程系,福建厦门361024

出　　处：《渔业研究》2021年第6期587-596,共10页Journal of Fisheries Research

基　　金：福建省省属公益类科研院所基本科研专项(2018R1003-11);福建省海洋与渔业结构调整专项(2021HYJG20).

摘　　要：本研究以流动性、均匀性、沉降系数和成本系数为指标,优化出复方紫海胆黄油软胶囊内容物配方为紫海胆黄油∶小麦胚芽油∶天然维生素E=3∶6∶1;采用单因素法和正交试验设计法,以胶液黏稠度、胶皮软硬程度和崩解时限为指标,优化出囊壁配方为明胶∶水∶甘油∶PEG400∶尼泊金乙酯=1∶1.1∶0.6∶0.05∶0.0025。按优化配方,采用旋转压制法等工艺制备获得复方紫海胆黄油软胶囊产品,其水分(0.20±0.016)%、装量差异(≤8%)、崩解时限(11.31±0.25)min和微生物限度均符合《中华人民共和国药典2015年版》通则0103“胶囊剂”的规定。研究为进一步开展软胶囊中试放大生产提供了数据支持,为海洋膳食脂质的应用及产业健康发展提供了技术参考。Based on the indices of fluidity,uniformity,sedimentation coefficient and cost coefficient,the optimal formula of softgel inner fill was determined as Heliocidaris crassispina gonad oil∶wheat-germ oil∶α-tocopherol with mass ratio of 3∶6∶1.Based on the indexes of viscosity,hardness and disintegration time,the softgel wall formula was optimized as gelatin∶deionized water∶glycerol∶polyethylene glycol 400∶ethylparaben with mass ratio of 1∶1.1∶0.6∶0.05∶0.0025 by using the single-factor method and orthogonal experimental design.The softgels were manufactured according to the above-mentioned optimal formulas by utilizing the softgels encapsulation machine with rotary pressing method.The moisture contents(0.20±0.016)%,set quantity deviations(≤8%),disintegration times(11.31±0.25)min and microbes amount of the softgels of H.crassispina gonad oil complex had met the criteria of 0103 Capsules,2015 year edition of the Pharmacopoeia of the People's Republic of China.Aiming to provide novel dietary lipid products from marine resources as well as related manufacturing technology parameters,this study has provided scientific data and theoretical projections for bio-diversified application of dietary lipids and better development of dietary lipids industry in China.

关 键 词：紫海胆黄 脂质 软胶囊 配方 制备工艺 

分 类 号：TS254.4[轻工技术与工程—水产品加工及贮藏工程] R944.5[轻工技术与工程—食品科学与工程]