癌症恶病质的病理生理及发病机制:恶病质治疗的方向  

Pathophysiology and pathogenesis of cancer cachexia:the direction of cachexia treatment

作　　者：何国平 邱鸣寒 赵轩竹 梅汉玮 齐瑞丽 王华庆[2,3] HE Guoping;QIU Minghan;ZHAO Xuanzhu;MEI Hanwei;QI Ruili;WANG Huaqing(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学研究生院,天津301617 [2]南开大学人民医院肿瘤科,300121 [3]开大学人民医院转化医学研究院,300121

出　　处：《临床肿瘤学杂志》2021年第11期1028-1035,共8页Chinese Clinical Oncology

基　　金：国家自然科学基金资助项目(82070206)。

摘　　要：癌症恶病质是一种多因素综合征,其特征是体重降低、厌食和骨骼肌萎缩。既往这种综合征被认为是不可治愈的,但在最近几年,随着对这种疾病的病理生理改变及发病机制的了解,癌症恶病质的治疗已经取得了一些重要的进展。虽然癌症恶病质的发生、发展所涉及的分子机制异常复杂,但其病理变化是一致的。在这篇综述中,我们主要从恶病质病理变化的角度概述了与骨骼肌萎缩、脂肪组织丢失/褐变、食欲减退有关的恶病质介质和途径的最新知识,并追溯迄今为止开发的治疗方案。Cancer cachexia is a multifactorial syndrome characterized by weight loss,anorexia,and skeletal muscle atrophy.In the past,this syndrome was considered incurable,but in recent years,with the understanding of the pathophysiological changes and pathogenesis of this disease,some important progress has been made in the treatment of cancer cachexia.Although the molecular mechanisms involved in the occurrence and development of cancer cachexia are extremely complex,their pathological changes are consistent.In this review,we mainly summarize the latest knowledge of cachexia mediators and pathways related to skeletal muscle atrophy,adipose tissue loss/browning,and loss of appetite from the perspective of pathological changes in cachexia,and then trace back the treatment options developed so far.

关 键 词：癌症 恶病质 机制 治疗 

分 类 号：R730.6[医药卫生—肿瘤]