表观遗传学在肿瘤放射性DNA损伤修复中的研究进展  

Research progress on epigenetics in the repair of radiation-induced DNA damage in tumors

作　　者：揭小华 徐双兵 伍钢[1] Jie Xiaohua;Xu Shuangbing;Wu Gang(Cancer Center,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430023,China)

机构地区：[1]华中科技大学同济医学院附属协和医院肿瘤中心,武汉430023

出　　处：《中华放射肿瘤学杂志》2021年第12期1335-1339,共5页Chinese Journal of Radiation Oncology

基　　金：国家自然科学基金(81874218)。

摘　　要：放疗通过放射线诱导肿瘤细胞DNA双链断裂来治疗癌症,但肿瘤细胞中异常的DNA双链断裂修复往往会导致放疗抵抗,而表观遗传学在其中发挥至关重要作用。靶向表观遗传学相关的重要分子可能是潜在的肿瘤放射增敏手段,但将表观遗传学药物与放疗联合的临床应用还需要进一步的机制研究。本文将对表观遗传学在肿瘤放射性DNA损伤修复中的作用最新进展进行综述。Radiotherapy kills tumor cells by radiation-induced DNA double-strand breaks(DSB),however,abnormal DSB repair in tumor cells often leads to radioresistance,in which epigenetics plays an important role.Targeting aberrant epigenetic markers may be a potential means of cancer radiosensitization,but the clinical application of the combination of epigenetic drugs and radiotherapy requires further investigation.This article reviews the latest research progress the role of epigenetics in the repair of radiation-induced DNA damage in tumors.

关 键 词：表观遗传学 放射性DNA损伤修复 肿瘤/放射疗法 

分 类 号：R730.55[医药卫生—肿瘤]