普罗布考联合瑞舒伐他汀对脑梗死患者炎症介质及相关实验室检查指标的影响  

Effect of Probucol combined with Rosuvastatin on inflammatory mediators and related laboratory indexes in patients with cerebral infarction

作　　者：张艺丹[1] 徐初川 于子雯 刘林 ZHANG Yi-dan;XU Chu-chuan;YU Zi-wen;LIU Lin(Department of Neurology,the First Affiliated Hospital of Xiamen University,Fujian Province,Xiamen361003,China)

机构地区：[1]厦门大学附属第一医院神经内科,福建厦门361003

出　　处：《中国当代医药》2021年第34期43-45,53,共4页China Modern Medicine

摘　　要：目的探究普罗布考联合瑞舒伐他汀对脑梗死患者炎症介质及相关实验室检查指标的影响。方法选择2019年12月至2021年2月厦门大学附属第一医院收治的脑梗死患者106例,按随机数字表法分为对照组(53例)和观察组(53例)。对照组采用瑞舒伐他汀治疗,观察组在对照组基础上加用普罗布考治疗。比较两组炎症介质、血清神经元特异性烯醇化酶(NSE)、中枢神经系统特异性蛋白(S100β)、人甲壳质酶蛋白40(YKL-40)及血脂水平。结果观察组治疗后肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)及基质金属蛋白酶9(MMP-9)水平均低于对照组,NSE、S100β、YKL-40水平均低于对照组,三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)水平均低于对照组,高密度脂蛋白(HDL-C)高于对照组,差异有统计学意义(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论在脑梗死患者中采用普罗布考联合瑞舒伐他汀治疗可有效降低炎症反应,减轻神经损伤,调节血脂水平,促进神经功能改善,安全可靠。Objective To explore the effect of Probucol combined with Rosuvastatin on inflammatory mediators and related laboratory indicators in patients with cerebral infarction.Methods A total of 106 patients with cerebral infarction admitted to the First Affiliated Hospital of Xiamen University from December 2019 to February 2021 were selected and divided into control group(53 cases)and observation group(53 cases)according to the random number table method.The control group was treated with Rosuvastatin,and the observation group was treated with Probucol on the basis of the control group.The inflammatory mediators,serum neuron-specific enolase(NSE),central nervous system-specific protein(S100β),human chitinase protein 40(YKL-40)and blood lipid levels were compared between the two groups.Results After treatment in the observation group,tumor necrosis factor-α(TNF-α),procalcitonin(PCT),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and matrix metalloproteinase 9(MMP-9)level were lower than those in the control group,the levels of NSE,S100β,and YKL-40 were lower than those in the control group,and the levels of total cholesterol(TG),total cholesterol(TC),and low-density lipoprotein(LDL-C)were lower those in the control group,high-density lipoprotein(HDL-C)was higher than that in the control group,the differences were statistically significant(P<0.05);the difference between the two groups of adverse reactions was not statistically significant(P>0.05).Conclusion Probucol combined with Rosuvastatin treatment in patients with cerebral infarction can effectively reduce inflammation,reduce nerve damage,regulate blood lipid levels,and promote neurological function improvement.It is safe and reliable.

关 键 词：脑梗死 普罗布考 瑞舒伐他汀 炎症介质 神经功能 血脂 

分 类 号：R743.3[医药卫生—神经病学与精神病学]