阿立哌唑与利培酮治疗精神分裂症的临床效果及对糖脂代谢的影响比较  

Clinical effect of Aripiprazole and Risperidone in the treatment of schizo-phrenia and comparison of their effect on glucose and lipid metabolism

作　　者：屈金梅[1] QU Jin-mei(Department of Pharmacy,Jiuquan People′s Hospital,Gansu Province,Jiuquan735000,China)

机构地区：[1]甘肃省酒泉市人民医院药剂科,甘肃酒泉735000

出　　处：《中国当代医药》2021年第34期173-176,共4页China Modern Medicine

摘　　要：目的探讨阿立哌唑与利培酮治疗精神分裂症的临床效果及对糖脂代谢的影响。方法选取2018年6月至2019年8月酒泉市人民医院收治的70例精神分裂症患者作为研究对象,采用随机数字表法将其分为对照组和观察组,每组各35例。对照组患者采用利培酮治疗,观察组患者采用阿哌利唑。比较两组患者的血糖、血脂水平以及临床疗效。结果治疗前,两组患者的空腹血糖(FBG)、餐后2 h血糖(2 h PG)水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者的FBG、2 h PG水平低于对照组,差异有统计学意义(P<0.05);两组患者治疗后的FBG、2 h PG水平高于治疗前,差异有统计学意义(P<0.05)。治疗前,两组患者的胆固醇(TC)、三酰甘油(TG)、低密脂蛋白胆固醇(LDL-C)水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者的TC、TG和LDL-C水平低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的HDL-C水平高于对照组,差异有统计学意义(P<0.05);观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论与利培酮相比,阿立哌唑治疗精神分裂症患者的效果更佳显著,能显著改善患者的血糖及血脂水平,值得推广。Objective To explore the clinical effect of Aripiprazole and Risperidone in the treatment of schizophrenia and comparisons of their effect on glucose and lipid metabolism.Methods Seventy patients with schizophrenia in Jiuquan People′s Hospital from June 2018 to August 2019 were selected as the research subjects.They were divided into a control group and an observation group by the random number table method,with 35 cases in each group.The patients in the control group were treated with Risperidone,and the patients in the observation group were treated with Aripiprazole.The blood glucose,blood lipid levels and clinical efficacy of the two groups of patients were compared.Results Before treatment,there were no statistically significant differences in the levels of fasting blood glucose(FBG)or 2-hour postprandial glucose(2 h PG)between the two groups(P>0.05).After treatment,the FBG and 2 h PG levels of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The levels of FBG and 2 h PG in the two groups after treatment were higher than those before treatment,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of cholesterol(TC),triacylglycerol(TG),or low-density lipoprotein cholesterol(LDL-C)between the two groups.After treatment,the levels of TC,TG and LDL-C in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The HDL-C level of observation group was higher than that in the control group after treatment,the difference was statistically significant(P<0.05).The total effective rate of observation group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion Compared with Risperidone,Aripiprazole has a significant effect on treating patients with schizophrenia,and can remarkably improve the blood glucose and blood lipid levels,which is worthy of promotion.

关 键 词：阿立哌唑 利培酮 精神分裂症 临床疗效 糖脂代谢 

分 类 号：R749.3[医药卫生—神经病学与精神病学]