芩连疏肝理脾汤联合羟氯喹对口腔扁平苔癣(肝郁脾虚型)患者血清ALT、UA水平的影响  

Effect of Qinlian Shugan Lipi Decoction Combined with Hydroxychloroquine on Levels of Serum ALT and UA for Patients with Liver-stagnation and Spleen-deficiency Type Oral Lichen Planus

作　　者：胡智 HU Zhi(Jiangxia District Hospital of Traditional Chinese Medicine,Hubei Wuhan 430200,China)

机构地区：[1]武汉市江夏区中医院,湖北武汉430200

出　　处：《四川中医》2021年第11期190-193,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察芩连疏肝理脾汤联合羟氯喹对口腔扁平苔癣(OLP)(肝郁脾虚型)患者血清丙氨酸氨基转移酶(ALT)、尿酸(UA)水平的影响。方法:选取2019年10月~2020年10月于我院收治的94例肝郁脾虚型OLP患者为研究对象,使用随机数字表法分为对照组(n=47)和观察组(n=47)。对照组患者予以羟氯喹治疗,观察组患者在对照组基础上予以自拟芩连疏肝理脾汤治疗。评估两组患者治疗4周后疗效差异,比较两组患者治疗前、治疗4周后中医症候积分、血清肝酶[ALT、天门冬氨酸氨基转移酶(AST)、磷酸肌酸激酶(CK)]、血清指标[UA、甘油三酯(TG)]差异,观察两组患者治疗期间药物不良反应差异。结果:治疗4周后,两组患者疗效差异显著,观察组患者总有效率高于对照组(P均<0.05);两组患者口糜疼痛、口干目干、心烦易燥、纳呆、不寐中医症候积分得分较治疗前降低,且观察组低于同期对照组(P均<0.05);两组患者血清ALT、AST、TG均较治疗前下降,且观察组低于同期对照组;两组患者血清CK、UA均较治疗前上升,且观察组高于同期对照组(P均<0.05);治疗期间,两组患者不良反应发生差异不显著(Fisher精确概率=1.000)。结论:芩连疏肝理脾汤联合羟氯喹对OLP(肝郁脾虚型)患者疗效显著,能明显减轻患者中医症状,对控制血清ALT、UA均有显著效果,且安全性较好。Objective:To explore the effect of Qinlian Shugan Lipi Decoction combined with Hydroxychloroquine on levels of serum alanine aminotransferase(ALT)and uric acid(UA)for patients with liver-stagnation and spleen-deficiency type oral lichen planus(OLP).Methods:Ninety-four patients with OLP of liver stagnation and spleen deficiency type who were admitted to our hospital from October 2019 to October 2020 were selected as the research subjects,and they were divided into a controlled group(n=47)and an observation group(n=47)by using the random number table method.Patients in the controlled group were treated with Hydroxychloroquine,and patients in the observation group were treated with Self-made Qinlian Shugan Lipi Decoction on the basis of the controlled group.The difference in efficacy was evaluated in the two groups of patients after 4 weeks of treatment,and the TCM syndromes scores,serum liver enzymes[ALT,aspartate aminotransferase(AST),creatine phosphate kinase(CK)]and serum indicators[UA,triglyceride(TG)]were compared between the two groups before treatment and after 4 weeks of treatment.The differences in adverse drug reactions were observed in the two groups of patients during treatment.Results:After 4 weeks of treatment,there was a significant difference in efficacy between the two groups of patients,and the total effective rate of the observation group was higher than that of the controlled group(P<0.05).The scores of TCM syndromes of oral ulceration pain,dry mouth and eyes,dysphoria,anorexia and insomnia in the two groups were decreased compared with those before treatment,and the scores of the observation group were lower than those of the controlled group during the same period(P<0.05).The levels of serum ALT,AST and TG of the two groups of patients were lower than those before treatment,and the levels of the observation group were lower than those of the controlled group during the same period.The levels of serum CK and UA of patients in the two groups were higher than those before treatment,and the levels

关 键 词：芩连疏肝理脾汤 羟氯喹 口腔扁平苔癣 ALT UA 

分 类 号：R781.5[医药卫生—口腔医学]