维甲酸受体相关孤核受体α作为肿瘤治疗潜在靶点的研究进展  

Research progress of retinoic acid receptor-related orphan nuclear receptor αas a potential target of tumor therapy

作　　者：陈海飞 王天笑 石焕英 钟明康 李群益 施孝金 CHEN Haifei;WANG Tianxiao;SHI Huanying;ZHONG Mingkang;LI Qunyi;SHI Xiaojin(Department of Pharmacy,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院药剂科,上海200040

出　　处：《上海医药》2021年第23期8-11,82,共5页Shanghai Medical & Pharmaceutical Journal

基　　金：国家自然科学基金面上项目(81973399);国家自然科学基金青年科学基金项目(81901399、82001399);上海市“医苑新星”青年医学人才培养资助计划——临床药师项目;上海市重点临床专科项目——临床药学项目(shslczdzk06502);上海市科学技术委员会“科技创新行动计划”扬帆计划项目(20YF1404100)。

摘　　要：维甲酸受体相关孤核受体α(retinoic acid receptor-related orphan nuclear receptorα,RORα)属于核受体甾体激素受体家族成员,其是一种转录因子,在多种生理、病理过程中起着关键的调节作用。近年来,越来越多的证据表明,RORα参与多种恶性肿瘤的发生、发展过程,故被认为是肿瘤治疗的潜在靶点。本文介绍RORα在几种常见肿瘤中的作用及其机制的研究进展,为RORα在肿瘤治疗领域的基础研究和临床转化研究提供参考。Retinoic acid receptor-related orphan nuclear receptor α(RORα) is a member of nuclear steroid hormone receptor family and a ligand-dependent transcription factor,which plays a key regulatory role in a variety of physiological and pathological processes.In recent years,more and more evidence has shown that RORα is involved in the occurrence and progress of many malignant tumors and regarded as a potential therapeutic target.This paper focuses on the effects and mechanisms of RORα in several common tumors so as to provide theoretical reference for the basic and clinical transformation research of RORαin the field of tumor therapy.

关 键 词：维甲酸受体相关孤核受体α 肿瘤治疗靶点 转录因子 

分 类 号：R730.23[医药卫生—肿瘤] R979.19[医药卫生—临床医学]