氟米龙滴眼液治疗干眼有效性及安全性的系统评价  

Systematic evaluation of the efficacy and safety of fluorometholone eye drops in the treatment of dry eyes

作　　者：王咏丽 李红梅[1] 佟欣[2] 吕小红 张霞[1] 刘红梅[1] WANG Yongli;LI Hongmei;TONG Xin;LYU Xiaohong;ZHANG Xia;LIU Hongmei(Department of General Internal Medicine,Northern Medical District of Chinese PLA General Hospital,Beijing100094,China;Department of Qinghe Outpatient,Northern Medical District of Chinese PLA General Hospital,Beijing100085,China)

机构地区：[1]中国人民解放军总医院京北医疗区综合内科,北京100094 [2]中国人民解放军总医院京北医疗区清河门诊部,北京100085

出　　处：《中国现代医生》2021年第30期18-21,25,F0003,共6页China Modern Doctor

摘　　要：目的系统评价氟米龙滴眼液联合玻璃酸钠滴眼液治疗干眼的有效性和安全性。方法按Cochrane系统评价方法,检索Pubmed、Cochrane图书馆、CBM、CNKI、VIP和万方等数据库,纳入氟米龙滴眼液联合玻璃酸钠滴眼液治疗干眼的随机对照研究,时间从2010年1月至2020年1月进行Meta分析,采用RevMan5.3软件。结果共纳入7篇随机对照试验,共659例受试者,其中干预组336例,对照组323例。Meta分析结果显示,氟米龙滴眼液联合玻璃酸钠滴眼液在泪膜破裂时间[MD=3.11,95%CI(2.28~3.93),P<0.00001]、泪液分泌试验[MD=1.63,95%CI (0.28~2.98),P<0.05]、角膜荧光素染色[MD=-1.01,95%CI (-1.61~0.42),P<0.001]、总有效率[MD=5.34,95%CI(2.57~11.09),P<0.00001]等方面更优。两组均无严重的不良反应。结论氟米龙滴眼液联合玻璃酸钠滴眼液治疗干眼症优于单独用玻璃酸钠滴眼液。Objective To systematically evaluate the efficacy and safety of fluorometholone eye drops combined with sodium hyaluronate eye drops in the treatment of dry eyes. Methods According to the Cochrane systematic review method, Pubmed, Cochrane Library, CBM, CNKI, VIP, Wanfang and other databases were searched, and the randomized controlled studies of fluorometholone eye drops combined with sodium hyaluronate eye drops in the treatment of dry eyes were included. The study period was from January 2010 to January 2020. Meta-analysis was performed using RevMan5.3 software. Results A total of 7 randomized controlled trials with 659 subjects were included,including336 subjects in the intervention group and 323 subjects in the control group. According to the meta-analysis results,the combination treatment of fluorometholone eye drops and sodium hyaluronate eye drops showed superior performance in terms of tear film break-up time [MD=3.11,95%CI(2.28-3.93), P<0.00001], tear secretion test [MD=1.63,95%CI(0.28-2.98),P<0.05], corneal fluorescein staining [MD=-1.01,95%CI(-1.61-0.42),P<0.001] and total effective rate[MD=5.34,95%CI(2.57-11.09), P<0.00001]. There were no serious adverse reactions in the two groups. Conclusion The effect of Flumetholone eye drops combined with sodium hyaluronate eye drops is better than that of sodium hyaluronate eye drops alone in the treatment of dry eyes.

关 键 词：干眼症 氟米龙 玻璃酸钠 人工泪液 META分析 

分 类 号：R777.34[医药卫生—眼科]