Largeπ-extended donor-acceptor polymers for highly efficient in vivo near-infrared photoacoustic imaging and photothermal tumor therapy  

作　　者：Jiangao Li Hanlin Ou Jing Li Xiaodi Yang Congwu Ge Dan Ding Xike Gao 

机构地区：[1]Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai,200032,China [2]State Key Laboratory of Medicinal Chemical Biology,Key Laboratory of Bioactive Materials,Ministry of Education,College of Life Sciences,Nankai University,Tianjin,300071,China [3]China Innovation Research Institute of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,China

出　　处：《Science China Chemistry》2021年第12期2180-2192,共13页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21674126,21790362,51873092,51961160730,31900983);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB12010100);the Science and Technology Commission of Shanghai Municipality(19XD1424700,18JC1410600,21QA1411100);the Tianjin Science Found for Distinguished Young Scholars(19JCJQJC61200);China Postdoctoral Science Foundation Grant(2019M660983)。

摘　　要：Semiconducting polymers(SPs)with intensive near-infrared(NIR)absorption and high photothermal conversion efficiencies have been employed as a new generation of photothermal agents(PTAs)for“all-in-one”theranostic nanoplatforms with integrated photoacoustic imaging(PAI)and photothermal therapy(PTT)functions.However,the lack of facile molecular design principles impedes the development of highly efficient NIR PTAs.Herein,a facile molecular design strategy based on largeπ-extended donor-acceptor(L-π-D-A)structure is reported for achieving SPs(SP1-SP3)with highly efficient in vitro and in vivo PAI and PTT capabilities.Through adjusting the conjugation length and planarity of the donor units,both SP3 and corresponding nanoparticle(SPN)SPN3 exhibit stronger D-A strength,intensive NIR absorption,enhanced absorption coefficient,and higher photothermal conversion efficiency(up to 61.8%).The excellent photothermal conversion efficiencies make SPN1-SPN3 produce efficient inhibition of tumor growth with excellent biocompatibility and prominent PAI performance with a high contrast manner in living mice at a low systemic injection mass.Our research highlights that the new L-π-D-A molecular design is an effective strategy to obtain highly efficient polymeric NIR PTAs for high desirable cancer phototheranostic nanoplatforms.

关 键 词：D-A polymers NEAR-INFRARED photothermal agents photoacoustic imaging photothermal therapy 

分 类 号：R730.5[医药卫生—肿瘤] TQ317[医药卫生—临床医学]