Ultrasound-propelled Janus Au NR-mSiO_(2) nanomotor for NIR-II photoacoustic imaging guided sonodynamic-gas therapy of large tumors  

作　　者：Jiamin Ye Qinrui Fu Luntao Liu Lanlan Chen Xuan Zhang Qingqing Li Zhi Li Lichao Su Rong Zhu Jibin Song Huanghao Yang 

机构地区：[1]MOE Key Laboratory for Analytical Science of Food Safety and Biology,Ministry of Education,College of Chemistry,Fuzhou University,Fuzhou,350108,China

出　　处：《Science China Chemistry》2021年第12期2218-2229,共12页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21874024,22027805,21804068);the National Key R&D Program of China(2020YFA0210800);the joint re-search projects of Health and Education Commission of Fujian Province(2019-WJ-20);the Natural Science Foundation of Fujian Province(2020J02012)。

摘　　要：Varieties of contrast agents have been developed for photoacoustic(PA)and ultrasound(US)imaging of cancers in vivo.However,access of traditional contrast agents into the sites of tumors has been principally through passive infiltration without any external force,preventing their deep penetration into the tissues of the tumors,and hindering the use of PA and US for deep tumor imaging.The concept of micro/nanomotors has been the focus of increasing attention as active theranostic agents due to their active movement in particular fluids,thereby conducting assigned tasks.Herein,US-propelled Janus mesoporous SiO_(2)partially coated gold nanorods(Au NR-mSiO_(2))were fabricated for deep tumor NIR-II PA imaging and synergistic sonodynamic-gas therapy.Following US irradiation,2,2-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride(AIPH)loaded in mSiO_(2)(Au NR-mSiO_(2)/AIPH)generated N_(2)microbubbles with high efficiency to achieve nanomotor drive.Due to the deep penetration of US,the nanomotors exhibited a capability to travel deep within sites of tumors,providing enhanced PA/US imaging inside the tumors.Furthermore,the nanomotor based cancer therapy was demonstrated through synergistic N_(2)gas and sonodynamic therapy.The US-propelled nanomotors demonstrated a novel strategy for the simultaneous PA/US dual imaging deep within tumor tissues and precise therapy of large tumors.

关 键 词：NANOMOTOR NIR-Ⅱphotoacoustic imaging ULTRASOUND sonodynamic therapy gas therapy 

分 类 号：R730.5[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]