铁超载在非酒精性脂肪性肝病中的作用  

Role of iron overload in nonalcoholic fatty liver disease

作　　者：庞华珍 唐艳芳[2] 刘容 刘丽[2] 刘旭东[2] PANG Huazhen;TANG Yanfang;LIU Rong;LIU Li;LIU Xudong(Graduate School of Guangxi University of Traditional Chinese Medicine*banning 530008,China;Department of Hepatology,Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine,Nanning 530011,China)

机构地区：[1]广西中医药大学研究生院,广西南宁530008 [2]广西中医药大学附属瑞康医院肝病科,广西南宁530011

出　　处：《大连医科大学学报》2021年第5期451-455,共5页Journal of Dalian Medical University

基　　金：国家自然科学基金项目(82160837);广西科技攻关项目(桂科AB18221009);2019年广西一流学科建设课题(2019XK139);广西中医药大学岐黄工程高层次人才培育项目(2021007);2019年中医药传承与创新人才培养平台建设项目(国中医药人教函[2019] 41号)。

摘　　要：铁超载与非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)关系紧密,肝脏铁超载可分为原发性及继发性病因两大类,常规采用血清铁蛋白及核磁共振成像来评估。铁作为肝脏损伤和肝病进展的重要因素,通过使肝脏处于氧化应激状态和增加胰岛素抵抗产生肝损伤,并对多种免疫细胞产生影响,促进NAFLD进展至肝纤维化。治疗以去铁疗法/抗氧化剂的应用为主。本文对铁超载与NAFLD的关系,铁超载参与NAFLD疾病进展的机制,以及NAFLD铁超载的治疗进行综述。Iron overload is closely related to non-alcoholic fatty liver disease(NAFLD). Hepatic iron overload can be divided into primary and secondary causes. Serum ferritin and nuclear magnetic resonance imaging are routinely used to evaluate it. Iron, as an important factor in the progression of liver damage and liver disease, causes liver damage by putting the liver in a state of oxidative stress and increasing insulin resistance, and affects a variety of immune cells, thereby promoting the progression of NAFLD to liver fibrosis.Treatment is based on iron removal therapy/antioxidant application. In this article, we will summarize the relationship between iron overload and NAFLD, explain the mechanisms of iron overload involved in the progression of NAFLD disease, and summarize the treatment of iron overload in NAFLD.

关 键 词：非酒精性脂肪性肝病 铁超载 机制 

分 类 号：R57[医药卫生—消化系统]