原发性肝癌TACE术后发生感染性并发症的影响因素研究  

Factors Influencing TACE Postoperative Infectious Complications of Primary Liver Cancer

作　　者：马冰[1] 白黎 赵艳 海丹丹[1] 李花花[1] MA Bing;BAI Li;ZHAO Yan(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2021年第12期2033-2035,共3页The Practical Journal of Cancer

基　　金：河南省自然科学基金项目(编号:18010341440)。

摘　　要：目的研究分析原发性肝癌(PLC)经肝动脉栓塞化疗(TACE)术后发生感染性并发症的相关危险因素。方法回顾性分析行TACE治疗的259例PLC患者临床资料。调查并记录患者一般资料及病理资料,记录感染性并发症发生率,并分析相关危险因素。结果259例PLC患者TACE术后发生感染性并发症31例,发生率为11.97%(31/259);感染组、非感染组患者的肝功能分级、糖尿病史、乙型肝炎病毒DNA(HBV-DNA)、组织学分化程度、肿瘤直径、肝癌病程、乙型肝炎病程及白蛋白(ALB)对比,有统计学差异(P<0.05);两组患者的性别、肝外转移、手术史、饮酒史、吸烟史、年龄、体质量指数(BMI)、降钙素原(PCT)及血红蛋白(Hb)对比,无统计学差异(P>0.05)。采用Logistic回归分析显示,肝功能分级、糖尿病史、HBV-DNA、组织学分化、肿瘤直径、肝癌病程、乙型肝炎病程及ALB为PLC患者TACE术后发生感染性并发症的独立危险因素(P<0.05且OR≥1)。结论肝功能分级、糖尿病史、HBV-DNA、组织学分化、肿瘤直径、肝癌病程、乙型肝炎病程及ALB为PLC患者TACE术后发生感染性并发症的主要危险因素,临床上应该控制并改善相关危险因素以减少感染性并发症的发生。Objective To study the risk factors of infectious complications of primary liver cancer(PLC)after embolization chemotherapy(TACE)via hepatic artery.Methods Clinical data of 259 PLC patients treated in TACE were retrospectively analyzed.To investigate and record general and pathological data of patients,Record the incidence of infectious complications,and analyze the related risk factors.Results Of the 259 PLC patients treated with TACE,31 cases had postoperative infectious complications,incidence was 11.97%(31/259);liver function classification,diabetes history,hepatitis b virus DNA(hbv-DNA),histological differentiation,tumor diameter,liver cancer course,hepatitis b course and albumin(ALB)comparison in infected and non-infected patients,(a)There was statistical difference(P<0.05);Gender,extrahepatic metastasis,surgical history,drinking history,smoking history,age,body mass index(BMI),procalcitonin(PCT)and hemoglobin(Hb)were compared between the two groups,and there was no statistical difference(P>0.05).Based on Logistic regression analysis,the liver function grade,diabetes history,HBV-DNA,histological differentiation,tumor diameter,liver cancer course,hepatitis b course and ALB were independent risk factors for postoperative infectious complications in PLC patients(P<0.05)and(OR<1).Conclusions Liver function grade,diabetes history,HBV-DNA,histological differentiation,tumor diameter,liver cancer course,hepatitis B course and ALB are the main risk factors for postoperative infectious complications in PLC patients.The related risk factors should be controlled and improved clinically to reduce the occurrence of infectious complications.

关 键 词：原发性肝癌 经肝动脉栓塞化疗 感染性并发症 危险因素 

分 类 号：R735.7[医药卫生—肿瘤]