不同分期恶性肿瘤患者合并严重冠状动脉狭窄PCI术后CXCL13、INTβ1变化及远期预后  

The Changes and Long-term Prognosis of CXCL13 and INTβ1 After PCI in Patients with Different Clinical Stages of Malignant Tumor with Severe Coronary Stenosis

作　　者：张军丽[1] ZHANG Junli(Puyang Oilfield General Hospital,Puyang,457001)

机构地区：[1]河南省濮阳市油田总医院,457001

出　　处：《实用癌症杂志》2021年第12期2073-2076,共4页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划项目(编号:2018062136)。

摘　　要：目的探讨不同分期恶性肿瘤患者合并严重冠状动脉狭窄经皮冠状动脉介入(PCI)术后趋化因子(CXCL)13、整合素(INT)β1变化及远期预后。方法收集186例恶性肿瘤合并严重冠状动脉狭窄行PCI手术患者的临床资料,患者手术前后均行血清CXCL13、INTβ1检测,出院后长期随访,专人对资料进行回顾性的整理分析。结果早中期与晚期恶性肿瘤患者在PCI术前时血清CXCL13、INTβ1水平比较差异无统计学意义(P>0.05),PCI术后3d CXCL13、INTβ1较术前下降,晚期患者高于早中期患者,比较差异有统计学意义(P<0.05);早中期与晚期恶性肿瘤患者主要终点事件发生率分别为33.68%、69.23%,次要终点事件发生率分别为55.79%、89.01%,比较差异均有统计学意义(P<0.05)。相关性显示:恶性肿瘤患者PCI术后CXCL13、INTβ1水平与患者终点事件发生率间呈正相关(P<0.05)。结论不同分期恶性肿瘤患者合并严重冠状动脉狭窄PCI术后CXCL13、INTβ1变化及远期预后存在差异,晚期恶性肿瘤患者在PCI术后预后更差,术后CXCL13、INTβ1变化在一定程度上能反应患者预后情况。Objective To investigate the changes and long-term prognosis of chemokines(CXCL)13 and integrin(INT)β1 after percutaneous coronary intervention(PCI)in patients with different clinical stages of malignant tumor with severe coronary stenosis.Methods Clinical data of 186 cases of malignant tumor with severe coronary stenosis were collected,the serum CXCL13 and INTβ1 were detected before and after surgery,and long-term follow-up,the data were retrospectively sorted out and analyzed by special personnel.Results There was no significant difference in serum CXCL13 and INTβ1 levels between patients with early,middle and advanced malignant tumors in before PCI(P>0.05),CXCL13 and INTβ1 of 3 days after PCI were lower than those before PCI,the patients with advanced stages were higher than those with early and middle stages,the difference was statistically significant(P<0.05).The incidence of primary end point event in early,middle malignant tumors was 33.68%,the advanced malignant tumors was 69.23%,The incidences of secondary end point event were 55.79%and 89.01%,the difference was statistically significant(P<0.05).Correlation showed that there was a positive correlation between CXCL13 and INTβ1 levels and the incidence of end events in patients with malignant tumor after PCI(P<0.05).Conclusion CXCL13 and INTβ1 and long-term prognosis after PCI in patients with different stages of malignant tumor with severe coronary stenosis are different,patients with advanced malignancies have worse prognosis after PCI,postoperative changes of CXCL13 and I NTβ1 can reflect the prognosis of patients to a certain extent.

关 键 词：恶性肿瘤 临床分期 冠状动脉狭窄 经皮冠状动脉介入 趋化因子(CXCL)13 整合素(INT)β1 

分 类 号：R730.7[医药卫生—肿瘤]