选择性5-羟色胺再摄取抑制剂在胃食管反流病治疗中的应用现状  

The application status of selective serotonin reuptake inhibitors in the treatment of gastroesophageal reflux disease

作　　者：韩士举 林强 韩伟 孟宪博 王景杰 HAN Shiju;LIN Qiang;HAN Wei;MENG Xianbo;WANG Jingjie(Department of Gastroenterology,Tangdu Hospital,Xi′an 710038,China)

机构地区：[1]空军军医大学唐都医院消化内科,西安710038

出　　处：《实用医学杂志》2021年第22期2946-2949,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金(编号:81770534)。

摘　　要：胃食管反流病(gastroesophageal reflux disease,GERD)是常见易反复发作且发病机制多样的消化道慢性疾病,且精神心理因素在其中常扮演着重要角色,可通过影响食管运动感知、胃和十二指肠运动及中枢感觉敏化等机制参与GERD的发病和病情进展,临床上针对心身因素进行干预和治疗也取得了良好的效果,其中选择性5-羟色胺再摄取抑制剂(selective serotonin reuptake inhibitors,SSRIs)治疗效果显著,日益得到人们认可。本文将就心身因素在GERD发病中的可能机制及SSRI在GERD治疗中的机制和具体应用作一综述,以期为SSRI应用于GERD治疗提供临床依据。Gastroesophageal reflux disease(GERD)is a common chronic digestive diseases,which is easy to relapse and its pathogenesis is varied,and the spirit of psychological factors often play a key role in them.Psychological factors always play the important role in the pathogenesis and progression of GERD by influencing the mechanisms of esophageal motility and perception,gastric and duodenal motility and central sensory sensitization,and the intervention and treatment of mental factors also achieved good results,in which the selective serotonin reuptake inhibitors(SSRIs)has been recognized for its significant effects. This review summarized the possible mechanism of mental factors in the pathogenesis of GERD and the mechanism and specific application of SSRI in the treatment of GERD,so as to provide clinical reference for the application of SSRI in the clinical treatment of GERD.

关 键 词：选择性5羟色胺再摄取抑制剂 胃食管反流病 非腐蚀性反流性疾病 心身因素 

分 类 号：R571[医药卫生—消化系统]