腹部副神经节瘤的临床特征及长期预后分析  

Clinical features and long-term outcomes of abdominal paraganglioma

作　　者：周亚琼 严鹏 张华敏 杨怡 冯凯歌 陈秋宏 王秋林[1,2] 王沛坚 ZHOU Yaqiong;YAN Peng;ZHANG Huamin;YANG Yi;FENG Kaige;CHEN Qiuhong;WANG Qiulin;WANG Peijian(Department of Cardiovascular Medicine,the First Affiliated hospital of Chengdu Medical College,Chengdu 610500,China;Key Laboratory of Ageing and Vascular Homeostasis of Sichuan Higher Education Institude,Chengdu 610500,China;不详)

机构地区：[1]成都医学院第一附属医院心血管内科,成都610500 [2]衰老与血管稳态四川省高等学校重点实验室,成都610500

出　　处：《实用医学杂志》2021年第21期2743-2747,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:81970262)。

摘　　要：目的探讨腹部副神经节瘤(PGL)患者的临床病理特征及长期预后分析。方法对相关病例数据库进行回顾性检索,分析腹部PGL患者的临床病理特征和长期随访预后,应用Kaplan-Meier法进行生存分析,探讨腹部PGL术后复发及死亡的影响因素。结果共纳入24例患者,平均年龄58.9岁,肿瘤平均大小5 cm,主要位于肾下极以下。平均随访时间为54月。所有转移的患者肾上腺嗜铬细胞瘤评分(PASS)≥4分。1例患者出现同步转移,2例出现局部复发和远处转移。1例患者在诊断9年后死亡。经Kaplan-Meier曲线分析显示,PASS评分4~7分的患者复发或死亡的进展曲线明显高于PASS评分0~3分的患者(P=0.03)。结论腹部PGL是一种罕见且预后良好的肿瘤。然而,其复发风险高,因此长期随访十分重要,尤其是对于PASS≥4分的患者。Objective To investigate the clinicopathological features and long-term outcomes of patients with abdominal paraganglioma(PGL). Methods A retrospective study of relevant databases were performed to analyze theclinicopathological features and long-term follow-up outcomes of patients with abdominal PGL. KaplanMeier survival analysis was performed to explore the influencing factors of postoperative recurrence or death of abdominal PGL. Results A total of 24 patients were confirmed with abdominal PGL. The average age of diagnosis was 58.9 years. The average tumor size was 5 cm and they were predominantly located in the infrarenal position.The mean follow-up period was 54 months. All patients with metastases had pheochromocytoma of the Adrenal Gland Scaled Score(PASS)of ≥ 4. One patient presented with synchronous metastases while 2 developed local recurrence and distant metastases. One patient died 9 years after diagnosis. Kaplan-Meier curve analysis showed recurrence or death in patients with PASS score of 4 ~ 7 was significantly higher than patients with PASS score of 0~ 3(P = 0.03). Conclusions Abdominal PGL is a rare tumor with excellent long-term prognosis. Recurrence,although common,can occur decades after initial diagnosis. Long-term follow-up is therefore recommended for all patients with PGL,especially in patients with PASS of ≥ 4.

关 键 词：副神经节瘤 复发 手术 治疗 

分 类 号：R736.6[医药卫生—肿瘤]