加减蚕矢汤对强直性脊柱炎后凸畸形患者术后康复的影响  

Effect of modified Canshi decoction on postoperative rehabilitation in patients with ankylosing spondylitis kyphosis

作　　者：李一豪[1] 杨彬[1] LI Yihao;YANG Bin(He′nan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China)

机构地区：[1]河南省中医院,郑州450002

出　　处：《实用医学杂志》2021年第21期2799-2803,共5页The Journal of Practical Medicine

基　　金：国家中医临床研究基地科研专项课题(编号:2019JDZX055)。

摘　　要：目的观察加减蚕矢汤对强直性脊柱炎后凸畸形湿热痹阻证患者术后康复的影响。方法 80例患者术后随机分为对照组和观察组,分别口服甲氨蝶呤、加减蚕矢汤,疗程4周。观察两组BASMI、BASDAI、BASFI、中医证候。检测血清炎性因子(TNF-α、MIF、IL-1β、IL-6)、血清及关节液骨化相关蛋白(DKK-1、AMPK-α、SOST、FOXO3α)。观察两组临床疗效及安全性。结果观察组总有效率97.5%,高于对照组的80.0%(P <0.05)。与治疗后对照组比较,观察组BASMI、BASDAI、BASFI、中医证候、TNF-α、MIF、IL-1β、IL-6降低(P <0.05),血清及关节液DKK-1、AMPK-α、SOST、FOXO3α升高(P <0.05)。观察组不良反应发生率为2.5%,低于对照组的30.0%(P <0.05)。结论加减蚕矢汤可有效促进强直性脊柱炎后凸畸形湿热痹阻证患者的术后康复。Objective To observe the clinical effect modified Canshi decoction on postoperative rehabilitation in patients with ankylosing spondylitis kyphosis. Methods A total of 80 cases were randomly assigned to control group and observation group. Methotrexate and modified Canshi decoction were administered for 4 weeks to the two groups,respectively. The BASMI,BASDAI,BASFI,TCM symptoms were observed. The serum inflammatory factors(TNF-α,MIF,IL-1β,IL-6),serum and articular fluid ossification-associated proteins(DKK-1,AMPK-α,SOST,FOXO3 a)were detected. The clinical efficacy and safety were observed. Results The total effective rate was 97.5% in the observation group vs 80.0% in the control group(P < 0.05). Compared with the control group after treatment,the BASMI,BASDAI,BASFI,TCM syndromes,TNF-α,MIF,IL-1β,IL-6 were decreased in the observation group(P < 0.05),and the serum and articular fluid DKK-1,AMPK-α,SOST,FoxO3-α were increased in the observation group(P < 0.05). The incidence of adverse reactions was 2.5% in observation group vs. 30.0% in control group(P < 0.05). Conclusion Modified Canshi decoction could effectively promote postoperative rehabilitation of patients with ankylosing spondylitis kyphosis.

关 键 词：加减蚕矢汤 强直性脊柱炎 后凸畸形 湿热痹阻证 

分 类 号：R734.2[医药卫生—肿瘤]