上海市杨浦区社区居民大肠癌和癌前期病变危险因素的研究  

Risk factors of colorectal cancer and precancerous lesions in Yangpu District of Shanghai

作　　者：赵佳[1] 韩雪[2] 谢梦[2] 陈灵颖 ZHAO Jia;HAN Xue;XIE Meng;CHEN Ling-ying(Department of Chronic Disease Prevention and Control,Yangpu District of Shanghai Municipal Center for Disease Control,Shanghai 200090,China;Office of Yangpu District of Shanghai Municipal Center for Disease Control,Shanghai 200090,China)

机构地区：[1]上海市杨浦区疾病预防控制中心慢性病防制科,上海200090 [2]上海市杨浦区疾病预防控制中心办公室,上海200090

出　　处：《中华肿瘤防治杂志》2021年第22期1725-1729,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：上海市卫生健康委员会科研课题(201540105);上海市杨浦区卫生健康委员会重点学科B类(YP19ZB11)。

摘　　要：目的研究上海市杨浦区社区居民大肠癌变及癌前病变的危险因素,探索危险因素的变化情况,为全市慢性病预防控制策略的制定提供依据。方法2015-01-01-2017-06-30在杨浦区开展社区大肠癌筛查的同时,追加一份危险因素的问卷调查,通过大肠癌筛查数据库和杨浦区肿瘤管理数据库追踪队列的结局,并对调查问卷中的47个相关因素进行单因素χ^(2)检验和多因素Logistic回归分析。共计12732例调查数据纳入队列,将72例确诊为大肠癌与191例确诊为癌前期病变的患者作为病例组,将12469名健康人群作为对照组。结果病例组大肠癌及癌前期病变患者男性比例、年龄≥60岁、有慢性腹泻史、有粘液或血便史、有肠息肉史、有一级亲属肠癌史、有个人癌症史、有下消化道炎症史、现在吸烟、现在饮酒、有午睡习惯史的比例分别为52.09%、84.41%、6.46%、6.08%、15.97%、11.79%、15.97%、17.11%、16.73%、11.79%和49.43%,均高于对照组人群的38.58%、74.31%、3.83%、1.92%、2.63%、4.15%、4.27%、9.73%、8.71%和39.02%,差异均有统计学意义,均P<0.05。病例组和对照组食用叶类蔬菜和豆制品的各频率段的占比不同,组间差异有统计学意义,均P<0.05,其中病例组每周食用叶类蔬菜≥6d的比例为54.37%,低于对照组的63.89%,食用豆制品每周≥4 d的比例为15.21%,低于对照组的16.72%。多因素条件Logistic回归分析结果显示,男性、年龄≥60岁、有粘液或血便史、有肠息肉史、有一级亲属肠癌史、有个人癌症史、有下消化道炎症、现在吸烟是杨浦区老年居民患大肠癌的危险因素,食用叶类蔬菜频率≥6 d/周是杨浦区居民患大肠癌及大肠癌前期病变的保护因素。结论随着社会的发展、生活水平和健康意识的提高,社区居民大肠癌发生的危险因素也将会发生变化。不断监测大肠癌发生的危险因素变化,将有效地控制其发生和发展。Objective To analyze the risk factors for colorectal cancer(CRC) and precancerous lesions about the community residents in Yangpu District of Shanghai. By exploration for the change of risk factors with the change of the society and living standard in recent years, to provide the basis for the establishment of the city’s chronic disease prevention and control strategies. Methods From January 1, 2015 to June 30, 2017, at the same time of CRC screening for the community residents in Yangpu District, to add a questionnaire survey for risk factors of CRA and precancerous lesions. Then to track the result of the queue by the CRC screening database and the tumor management database of Yangpu District. The 47 related factors were analyzed by univariate χ^(2)test and multivariate Logistic regression analysis. A total of 12 732 cases were included in the cohort, 72 patients diagnosed with colorectal cancer and 191 patients with the diagnosis of precancerous lesions as case group and 12 469 healthy people as control group.Results Cases patients with colorectal cancer and precancerous lesions in the number of proportion of male, aged 60 and above, had the history of chronic diarrhea, had the history of mucus or blood, history of colon polyps, history of first-degree relatives colorectal cancer, had personal history, history of the digestive tract inflammation, cancer now history of smoking, drinking, siesta habit(52.09%,84.41%,6.46%,6.08%,15.97%,11.79%,15.97%,17.11%,16.73%,11.79%,49.43%)were higher than those in the control group(38.58%,74.31%,3.83%,1.92%,2.63%,4.15%,4.27%,9.73%,8.71%,39.02%),and the differences were statistically significant(all P<0.05).The proportion of eating leafy vegetables and bean products in each frequency band was different between the case group and the control group,and the difference was statistically significant(all P<0.05).The proportion of eating leafy vegetables≥6 days a week in the case group was 54.37%,which was lower than that in the control group(63.89%).The proportion of eating bea

关 键 词：大肠癌 癌前期病变 危险因素 LOGISTIC回归分析 

分 类 号：R735.3[医药卫生—肿瘤]