环状RNA参与调控糖尿病视网膜病变的研究进展  

Research progress of circular RNA involved in the regulation of diabetic retinopathy

作　　者：何润西[1] 徐铭超 黎晓冬 武海燕 谢学军[2] Run-Xi He;Ming-Chao Xu;Xiao-Dong Li;Hai-Yan Wu;Xue-Jun Xie(Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;Department of Ophthalmology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,Sichuan Province,China)

机构地区：[1]成都中医药大学,中国四川省成都市610075 [2]成都中医药大学附属医院眼科,中国四川省成都市610072

出　　处：《国际眼科杂志》2022年第1期49-52,共4页International Eye Science

基　　金：国家自然科学基金资助项目(No.81473735)。

摘　　要：糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病在眼部的慢性微血管并发症之一,导致糖尿病患者视觉质量下降甚至失明事件发生率不断提高。然而目前为止,导致DR的病理改变机制十分复杂且未完全阐明,临床治疗多根据DR不同分期采取对症治疗,如视网膜激光光凝治疗、抗血管内皮因子治疗、玻璃体切割及剥膜手术等,仍缺乏安全有效的治疗方法,因此有必要寻找新的诊治靶标。随着分子生物学分析技术的发展,环状RNA(circular RNA,circRNA)成为目前重要的研究热点之一。据报道在多种因素的刺激下,基因的调节表达——circRNA通过调节视网膜微血管周细胞、视网膜微血管内皮细胞、视网膜色素上皮细胞等功能,参与到视网膜基底膜增厚、血管渗漏、细胞凋亡、炎症反应及新生血管增生等病理性过程来调控DR发生发展。故本文主要阐述环状RNA、竞争性内源性RNA以及微小RNA在DR病理改变分子机制、治疗前景中的研究进展,以期为临床及基础研究提供一定的参考。Diabetic retinopathy(DR)is one of the chronic microvascular complications of diabetes mellitus in the eye,leading to an increasing incidence of visual quality loss and even blindness in diabetic patients.However,so far,the mechanism of pathological changes leading to DR is very complex and not completely elucidated,and clinical treatment is mostly based on different stages of DR with symptomatic treatment,such as retinal laser photocoagulation,anti-vascular endothelial factor treatment,vitreous excision and membrane peeling surgery,etc.There is still a lack of safe and effective treatment methods,and it is therefore necessary to find new targets for diagnosis and treatment.With the development of molecular biology analysis technology,circular RNA(circRNA)has become one of the important research hotspots at present.It is reported that under the stimulation of various factors,the regulated expression of genes-circRNA regulates the development of DR by regulating the functions of retinal microvascular pericytes,retinal microvascular endothelial cells,and retinal pigment epithelial cells,which are involved in the pathological processes such as retinal basement membrane thickening,vascular leakage,apoptosis,inflammatory response and neovascularization.Therefore,this paper focuses on the research progress of cyclic RNA,competitive endogenous RNA and microRNA in the molecular mechanism of DR pathological alterations and therapeutic prospects,in order to provide some reference for clinical and basic research.

关 键 词：环状RNA 基因调控 糖尿病视网膜病变 微小RNA 

分 类 号：R73[医药卫生—肿瘤]