银杏叶提取物注射液联合丁苯酞软胶囊治疗轻型卒中的临床疗效  

Clinical efficacy of Ginkgo biloba extract injection combined with butylphthalide soft capsules in the treatment of mild stroke

作　　者：李林[1] 刘良敏 LI Lin;LIU Liangmin(Department of Encephalopathy,Anyang Traditional Chinese Medicine Hospital,Anyang Henan 455000,China)

机构地区：[1]安阳市中医院脑病一科,河南安阳455000

出　　处：《临床研究》2021年第12期83-86,共4页Clinical Research

摘　　要：目的分析银杏叶提取物注射液、丁苯酞软胶囊联合用药对于轻型卒中的临床疗效。方法选取2019年2月至2021年1月期间安阳市中医院收治的轻型卒中患者80例作为研究对象,依据随机数字表法分成研究组与对照组,各40例。对照组接受丁苯酞软胶囊治疗,研究组给予丁苯酞软胶囊,同时给予银杏叶提取物注射液,对比两组治疗前后神经缺损状况[美国国立卫生院神经功能缺损评分(NIHSS评分)]、血清炎性因子水平[白细胞介素-6(IL-6)、超敏-C反应蛋白(hs-CRP)]、血液流变学指标及血管内皮功能[一氧化氮(NO)、内皮素(ET)],对比两组治疗过程中不良反应发生情况。结果治疗前两组NIHSS评分对比,差异无统计学意义(P>0.05);治疗8 d后,两组患者的NIHSS评分均降低(P<0.05),且研究组低于对照组(P<0.05);两组治疗前血清hs-CRP、IL-6水平对比,差异无统计学意义(P>0.05);治疗8 d后两组血清hs-CRP、IL-6水平均降低(P<0.05),且研究组比对照组低(P<0.05);两组治疗前血浆黏度、全血高切黏度、全血低切黏度、红细胞比容、血小板聚集率对比,差异无统计学意义(P>0.05);治疗8 d后,两组血浆黏度、全血高切黏度、全血低切黏度、红细胞比容、血小板聚集率均降低(P<0.05),且研究组低于对照组(P<0.05);两组治疗前血清ET、NO水平对比,差异无统计学意义(P>0.05);治疗8 d后,两组血清ET水平均降低(P<0.05),且研究组比对照组低(P<0.05);治疗8 d后,两组血清NO水平均升高(P<0.05),且研究组比对照组高(P<0.05)。两组治疗过程中不良反应发生率相比差异无显著性差异(P>0.05)。结论银杏叶提取物注射液、丁苯酞软胶囊联合用药对轻型卒中治疗效果显著,可改善神经缺损,抑制炎性反应,增强血管内皮功能,优化血液循环,且安全可靠。Objective To analyze the clinical efficacy of the combination of Ginkgo biloba extract injection and butylphthalide soft capsules for mild stroke.Methods From February 2019 to January 2021,80 cases of mild stroke patients admitted to Anyang Hospital of Traditional Chinese Medicine were selected as the research objects.According to the random number table method,they were divided into a study group and a control group,with 40 cases in each group.The control group received butylphthalide soft capsule treatment,the study group was given butylphthalide soft capsule and Ginkgo biloba extract injection at the same time.Nerve defect status of the two groups before and after treatment[National Institutes of Health Neurological Impairment Score(NIHSS Score)],serum inflammatory factor levels[interleukin-6(IL-6),high-sensitivity-Creactive protein(hs-CRP)],blood rheology indexes and vascular endothelial function[nitric oxide(NO),endothelin(ET)]were compared.The occurrence of adverse reactions during the treatment of the two groups was compared.Results There was no significant difference in the NIHSS scores of the two groups before treatment(P>0.05).After 8 days of treatment,the NIHSS scores of the two groups of patients decreased(P<0.05),and the study group was lower than the control group(P<0.05).There was no significant difference in serum hs-CRP and IL-6 levels between the two groups before treatment(P>0.05).After 8 days of treatment,the serum hs-CRP and IL-6 levels in the two groups decreased(P<0.05),and compared with the study group Control group was low(P<0.05).There was no significant difference in plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,hematocrit,and platelet aggregation rate before treatment between the two groups(P>0.05).After 8 days of treatment,the two groups of plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,hematocrit,and platelet aggregation rate decreased(P<0.05),and the study group was lower than the control group(P<0.05).Comparison

关 键 词：丁苯酞软胶囊 银杏叶提取物注射液 轻型卒中 神经缺损 血管内皮功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]