Post-mortem tissue proteomics reveals the pathogenesis of multi-organ injuries of COVID-19  

作　　者：Yang Qiu Di Wu Wanshan Ning Jiqian Xu Ting Shu Muhan Huang Rong Chen Jiancheng Zhang Yang Han Qingyu Yang Ruiting Li Xiaobo Yang Yaxin Wang Xiaojing Zou Shangwen Pan Chaolin Huang Yu Xue You Shang Xi Zhou 

机构地区：[1]State Key Laboratory of Virology,Wuhan Institute of Virology,Chinese Academy of Sciences,China [2]Joint Laboratory of Infectious Diseases and Health,Wuhan Institute of Virology and Wuhan Jinyintan Hospital,Wuhan Institute of Virology,Chinese Academy of Sciences,China [3]Center for Translational Medicine,Wuhan Jinyintan Hospital,China [4]M0E Key Laboratory of Molecular Biophysics,Hubei Bioinformatics and Molecular Imaging Key Laboratory,Center for Artificial Intelligence Biology,College of Life Science and Technology,Huazhong University of Science and Technology,China [5]Department of Clinical Laboratory,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,China [6]Department of Critical Care Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,China [7]Joint Laboratory of Infectious Diseases and Health,Wuhan Institute of Virology and Wuhan Jinyintan Hospital,Wuhan Jinyintan Hospital,China [8]Institute of Anesthesiology and Critical Care Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,China

出　　处：《National Science Review》2021年第11期84-87,共4页国家科学评论（英文版）

基　　金：supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB29010300toX.Z.);the National Natural Science Foundation of China(81873964 to Y.Q;81971818 and 81772047 to Y.S.,31930021 and 31970633 to Y.X.and 31970169 to X.Z.),a grant from the CAS Youth Innovation Promotion Association(2020332 to Y.Q.);the program for Huazhong University of Science and Technology(HUST)Academic Frontier Youth Team(to Y.X.);a grant from the Clinical Research Center for Anesthesiology of Hubei Province(2019ACA167).

摘　　要：Multi-organ injuries are a major complication of severe Coronavirus Disease 2019(COVID-19).However,its pathogenesis is barely understood.Herein;we profile host responses to fatal SARS-CoV-2 infection by performing quantitative proteomics of 19 post-mortem samples of 8 different organs or tissues,including lungs,liver,intestine,kidney;spleen,brain,heart and muscle,from 3 deceased COVID-19 victims during the first wave of the pandemic(Supplementary Fig.S1A and B,Tables SI-S3).

关 键 词：INJURIES PATHOGENESIS ORGANS 

分 类 号：R563.1[医药卫生—呼吸系统]