多磺酸粘多糖乳膏用于下睑外翻术后恢复的疗效观察  

Observation on the curative effect of mucopolysaccharides polysulfate cream for lower eyelid ectropion patients after operation

作　　者：袁莉莉 师茸[2] YUAN Lili;SHI Rong(Qingyang People's Hospital,Qingyang 745000,China)

机构地区：[1]甘肃省庆阳市人民医院,庆阳745000 [2]陕西省延安市人民医院,延安716000

出　　处：《中国中医眼科杂志》2021年第11期799-802,817,共5页China Journal of Chinese Ophthalmology

摘　　要：目的观察多磺酸粘多糖乳膏治疗下睑外翻术后眼眶周围水肿、瘀斑和瘢痕的疗效。方法选取2016年1月-2019年1月符合纳入标准的下睑外翻患者42例(42只眼),随机分为治疗组和对照组,每组各21例(21只眼)。治疗组术后予多磺酸粘多糖乳膏涂抹眶周,对照组术后予尿素乳膏涂抹眶周。2组均观察30 d。评估2组用药后眶周水肿、瘀斑和瘢痕的恢复程度。结果(1)水肿评分:治疗组术后7、14、30 d均较术后1 d减轻,差异均有统计学意义(t_(7d)=2.464,P=0.018;t_(14d)=3.213,P=0.003;t_(30d)=4.822,P=0.000)。对照组术后7、14、30 d均较术后1 d减轻,差异均有统计学意义(t_(7d)=2.137,P=0.039;t_(14d)=2.832,P=0.007;t_(30d)=3.092,P=0.004)。2组术后7、14、30 d比较,治疗组均较对照组减轻,差异均有统计学意义(t_(7d)=6.593,t_(14d)=13.468,t_(30d)=7.329,均P=0.000)。(2)瘀斑评分:治疗组术后7、14、30 d均较术后1 d减轻,差异均有统计学意义(t_(7d)=2.612,P=0.013;t_(14d)=3.473,P=0.001;t_(30d)=4.153,P=0.000)。对照组术后7、14、30 d均较术后1 d减轻,差异均有统计学意义(t_(7d)=2.331,P=0.025;t_(14d)=2.518,P=0.016;t_(30d)=3.227,P=0.002)。2组术后7、14、30 d比较,治疗组均较对照组减轻,差异均有统计学意义(t_(7d)=3.855,P=0.000;t_(14d)=2.408,P=0.021;t_(30d)=5.458,P=0.000)。(3)瘢痕评分:治疗组术后7、14、30 d均较术后1 d减轻,差异均有统计学意义(t_(7d)=2.283,P=0.028;t_(14d)=3.153,P=0.003;t_(30d)=4.031,P=0.000)。对照组术后7、14、30 d均较术后1 d减轻,差异均有统计学意义(t_(7d)=2.418,P=0.020;t_(14d)=2.662,P=0.011;t_(30d)=3.081,P=0.004)。2组术后14、30 d比较,治疗组均较对照组减轻,差异均有统计学意义(t_(14d)=2.050,P=0.049;t_(30d)=4.263,P=0.000)。结论多磺酸粘多糖乳膏可迅速缓解下睑外翻术后眶周水肿和瘀斑,并在预防下睑外翻术后瘢痕形成方面效果良好。OBJECTIVE To observe the effect of mucopolysaccharides polysulfate cream on periorbital edema,ecchymosis and scar after surgery for lower eyelid ectropion.METHODS A total of 42 cases(42 eyes)of lower eyelid ectropion patients meeting the inclusion criteria from January 2016 to January 2019 were selected and randomly divided into treatment group and control group,with 21 cases(21 eyes)in each group.After procedure,the treatment group was treated with mucopolysaccharides polysulfate cream and the control group was treated with urea cream.Both groups were observed for 30 days.The recovery degree of periorbital edema,ecchymosis and scar were evaluated.RESULTS(1)Edema score:In treatment group,compared with result of postoperative day one,scores of the 7^(th),14^(th) and 30th day after surgery decreased,with statistically significant differences(t_(7d)=2.464,P=0.018;t_(14d)=3.213,P=0.003;t_(30d)=4.822,P=0.000).In the control group,result of the 7^(th),14^(th),30th day after sur-gery were lower than day one after surgery and the differences were statistically significant(t_(7d)=2.137,P=0.039;t_(14d)=2.832,P=0.007;t_(30d)=3.092,P=0.004).Compared with the result of control group at the 7^(th),14^(th),30th day after surgery,the result of treatment group was significantly lower(t_(7d)=6.593,t_(14d)=13.468,t_(30d)=7.329,all P=0.000).(2)Ecchymosist score:In treatment group,compared with result of postoperative day one,scores of the 7^(th),14^(th),30th day after surgery were significantly lower(t_(7d)=2.612,P=0.013;t_(14d)=3.473,P=0.001;t_(30d)=4.153,P=0.000).In the control group,scores of the 7^(th),14^(th) and 30th day after surgery were lower than postoperative day one,and the differences were statistically significant(t_(7d)=2.331,P=0.025;t_(14d)=2.518,P=0.016;t_(30d)=3.227,P=0.002).Inter-group comparison showed that results of treatment group at the 7 th,14^(th) and 30th day after surgery were significantly lower than counterparts of the control group(t_(7d)=3.855,P=0.000;t_(14d)=2.408,P=0.021;t_(30d)=5.458,P=0.000).(3)Sc

关 键 词：多磺酸粘多糖乳膏 下睑外翻 水肿 瘀斑 瘢痕 

分 类 号：R777.1[医药卫生—眼科]