具体性记忆训练对首发抑郁障碍患者过度概括化自传体记忆的作用  

Memory specificity training for the intervention study of overgeneral autobiographical memory of patients with first-episode depression

作　　者：蒋萍[1] 柳艳松 蔚然 黄月香[2] 袁念[1] JIANG Ping;LIU Yan-song;WEI Ran;HUANG Yue-xiang;YUAN Nian(Department of Psychiatry,Suzhou Psychiatric Hospital,the Affiliated Guangji Hospital of Soochow University,Suzhou 215131,China)

机构地区：[1]苏州市广济医院精神科,215137 [2]苏州市广济医院临床心理科,215137

出　　处：《临床精神医学杂志》2021年第6期446-448,共3页Journal of Clinical Psychiatry

基　　金：江苏省卫生健康委科研项目(LGY2019013);苏州市科技局项目(SYSD2017140,SS201882,SS2019076,LCZX201719)。

摘　　要：目的:探讨具体记忆性训练(MEST)对首发抑郁障碍患者过度概括化自传体记忆(OGM)的作用。方法:将70例首发抑郁障碍患者随机分为试验组和对照组,两组在艾司西酞普兰抗抑郁治疗的基础上,试验组接受MEST;疗程均为4周。治疗前后采用汉密尔顿抑郁量表(HAMD-17)评估抑郁症状的变化,采用自传体记忆测验(AMT)评估OGM水平的变化。结果:①试验组HAMD治疗前后差值(F=5.27,P=0.02,η^(2)=0.08)、OGM积极词治疗前后差值(F=7.87,P=0.00,η^(2)=0.11)与OGM消极词治疗前后差值(F=4.94,P=0.03,η^(2)=0.07)显著高于对照组;②治疗后,试验组HAMD及OGM积极词和消极词评分显著下降,且显著低于对照组(P均<0.05);③治疗后,对照组仅HAMD评分显著下降(P<0.05);OGM积极词和消极词评分没有显著变化。结论:艾司西酞普兰联合MEST可更好地改善抑郁障碍患者的症状及OGM水平。Objective:To explore the effectiveness of memory specificity training(MEST)for overgeneral autobiographical memory(OGM)of patients with first-episode depression.Method:Seventy patients with first-episode depression were randomly divided into experimental group and control group.The experimental group received combination MEST and escitalopram for 4 weeks,the control group received only escitalopram therapy for 4 weeks.Before and after the intervention,all the patients'depression symptom was evaluated by Hamilton depression symptom scale(HAMD)and OGM lever was evalutated by autobiographical memory test(OGM),respectively.Results:①Compared with the control group,the experimental group(MEST)were higher in the difference of HAMD scores before and after treatment(F=5.27,P=0.02,η^(2)=0.08),the difference of positive OGM scores before and after treatment(F=7.87,P=0.00,η^(2)=0.11),the difference ofnegative OGM scores before and after treatment(F=4.94,P=0.03,η^(2)=0.07),all P<0.05;②In the experimental group,the total scores of HAMD,the positive OGM,and the negative OGM scores significantly reduced more after the intervention than before the intervention and the control group(P<0.05);③In the control group,the total score of HAMD were reduced significantly more after the intervention than before the intervention(P<0.05),but the positive OGM and the negative OGM scores had no significant changes.Conclusion:Escitapram combined with MEST may improve the OGM and depression for patients with first-episode depression.

关 键 词：首发抑郁障碍 过度概括化自传体记忆 具体性记忆训练 

分 类 号：R749.4[医药卫生—神经病学与精神病学]