MicroRNAs电化学生物传感器在乳腺癌检测中的研究进展  

Research Progress in microRNAs Electrochemical Biosensor for Breast Cancer Detection

作　　者：王若男 李淑荣[1] 孟佩俊[1] 张丽萍[1] 靳敏[1] 刘燕茹 罗利霞 Wang Ruonan;Li Shurong;Meng Peijun;Zhang Liping;Jin Min;Liu Yanru;Luo Lixia(School of Public Health,Baotou Medical College,Inner Mongolia University of Science arul Technology,Baotou,014040)

机构地区：[1]内蒙古科技大学包头医学院公共卫生学院,包头014040

出　　处：《化学通报》2021年第12期1274-1283,共10页Chemistry

基　　金：内蒙古自治区自然科学基金项目(2018LH01017);包头医学院博士科研启动基金(BSJJ201803);包头医学院教育教学改革研究项目(2019YWWJ-YB-21)资助;。

摘　　要：MicroRNAs是一类内源性非编码小RNA分子,可调控靶基因的表达。特异性microRNAs的失调在诸如癌症、心血管疾病、免疫疾病、神经退行性疾病和皮肤疾病等的发展过程中起着关键作用,常作为疾病早期诊断和预后的生物标志物。电化学生物传感器由于其灵敏、快速、成本低等优势,已经成为传统microRNAs检测方法的一种很有前途的替代方法。本文综述了基于microRNA电化学生物传感器检测乳腺癌的研究进展,并对其所构建的电化学生物传感器的检测方法进行了分析探讨。MicroRNAs are a class of endogenous,small non-coding RNA molecules,which can regulate target genes expression.Disorders of specific microRNAs play a key role in the development of cancers,cardiovascular diseases,immune diseases,neurodegenerative diseases and skin diseases,and they are often used as biomarkers for early diagnosis and prognosis of diseases.Electrochemical biosensors have become a promising alternative to traditional microRNAs detection methods due to their advantages of sensitivity,rapidity,and low cost.In this article,the research progress in breast cancer detection based on microRNA electrochemical biosensors are reviewed,and the detection methods of constructed electrochemical biosensors are analyzed and discussed.

关 键 词：乳腺癌 MICRORNAS 电化学生物传感器 信号放大 

分 类 号：R737.9[医药卫生—肿瘤]