One-Pot Three-Component Synthesis of 2-Methyl-3-aminobenzofurans Using Calcium Carbide as a Concise Solid Alkyne Source  

作　　者：Xiaolong Ma Zhiqiang Wang Zhenrong Liu Zheng Li 

机构地区：[1]College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou,Gansu,730070 China

出　　处：《Chinese Journal of Chemistry》2021年第11期2990-2994,共5页中国化学（英文版）

基　　金：The authors thank the National Natural Science Foundation of China(21462038);Key Laboratory of Eco-Environment-Related Polymer Materials of the Ministry of Education of China for their financial support for this work.

摘　　要：A one-pot three-component method for the synthesis of 2-methyl-3-aminobenzofurans using calcium carbide as a concise solid alkyne source,and salicylaldehydes and secondary amines as starting materials is described.This protocol has salient feature of the use of inexpensive,abundant and easy-to-handle alkyne source,avoiding the use of inflammable and explosive acetylene gas as an original alkyne source.In addition,step economy,satisfactory yield,and simple work-up procedure are also advantages of this route.

关 键 词：CYCLIZATION Multicomponent reactions Synthetic methods Calcium carbide Alkyne source BENZOFURAN 

分 类 号：O62[理学—有机化学]