成功老龄、常态老人与轻度认知功能障碍患者静息态功能磁共振局部一致性研究  

A study on the regional homogeneity of resting-state functional MRI in successful aging,usual aging and patients with mild cognitive impairment

作　　者：韩胜楠 吴雪桉 赵幸福[2] 汪腾龙 HAN Shengnan;WU Xuean;ZHAO Xingfu(School of Humanities and Management, Wannan Medical College, Wuhu 241002, China)

机构地区：[1]皖南医学院人文与管理学院,安徽芜湖241002 [2]无锡市精神卫生中心

出　　处：《精神医学杂志》2021年第5期412-418,共7页Journal of Psychiatry

基　　金：江苏省社会发展—面上项目(编号:BE2017624)。

摘　　要：目的探讨成功老龄(SA)、常态老人(UA)和轻度认知功能障碍(MCI)患者之间的神经认知特点及大脑区域自发性活动特征。方法选取成功老龄(SA)30名、常态老人(UA)30名和老年轻度认知功能障碍(MCI)患者24例。经临床访谈量表和神经认知量表评估,采用中国版阿尔茨海默病评定量表-认知(ADAS-Cog)评定认知功能,蒙特利尔认知评估量表(MoCA)评估患者的认知损伤情况,日常生活活动能力(ADL)评估日常生活能力,再采用美国磁共振扫描仪进行收集。比较三组被试Reho值的差异。结果三组ADAS-Cog总分,MMSE总分及定向力、记忆力、计算、回忆力、语言能力因子分,MoCA总分及定向、抽象、延迟回忆、视知觉因子分比较差异均有统计学意义(P<0.05)。三组右侧小脑9区、左侧海马、右侧苍白球、左侧苍白球、左侧三角部额下回、右侧颞上回、右侧楔叶、右侧枕上回、左侧背外侧额上回、右侧额中回、右侧中央后回、右侧楔前叶和左侧旁中央小叶等区域差异有统计学意义(P-value<0.05,AphaSim矫正voxel size>18,P<0.01)。结论Reho结合神经心理测验可成为识别MCI和预测发展的指标。Objective To explore the neurocognitive characteristics and spontaneous activity of brain regions among successful aging(SA),usual aging(UA)and patients with mild cognitive impairment(MCI).Methods 30 successfully aged(SA)elderly persons,30 elderly persons of usual aging(UA),and 24 patients with mild cognitive impairment(MCI)were selected and assessed with clinical interview scale and neurocognitive scale assessment,Chinese version of Alzheimer’s Disease Assessment Scale-Cognition(ADAS-Cog),Montreal Cognitive Assessment(MoCA)and Activity of Daily Living Scale(ADL),and then collected using American magnetic resonance scanner.The differences in Reho values among three groups were compared.Results There existed statistically significant differences in the total scores of ADAS-Cog,the total scores and factor scores of orientation,memory,calculation,recall,language ability of MMSE,the total scores and factor scores of orientation,abstraction,delayed recall,visual perception of MoCA among three groups(P<0.05).Right cerebellar area 9,left hippocampus,right globus pallidus,left globus pallidus,left triangle inferior frontal gyrus,right superior temporal gyrus,right cuneiform lobe,right superior occipital gyrus,left dorsolateral superior frontal gyrus,right middle frontal gyrus,right central posterior gyrus,right precuneus and left paracentral lobule among three groups had statistically significant differences(P-value<0.05,AphaSim correction voxel size>18,P<0.01).Conclusion Reho combined with neuropsychological tests can be used as indicators to identify MCI and predict its development.

关 键 词：成功老龄 轻度认知功能障碍 静息态功能磁共振成像 神经认知 

分 类 号：R749.16[医药卫生—神经病学与精神病学]