强迫症患者错误相关负波特征及机制研究进展  

Characteristics and mechanism of error-related negativity in patients with obsessive-compulsive disorder

作　　者：曹文文 王鹏翀 杨祥云 李占江 Cao Wenwen;Wang Pengchong;Yang Xiangyun;Li Zhanjiang(The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China)

机构地区：[1]首都医科大学附属北京安定医院,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,100088

出　　处：《中华精神科杂志》2021年第6期409-414,共6页Chinese Journal of Psychiatry

基　　金：北京市医院管理中心临床医学发展专项经费资助(XMLX202129);北京市属医院科研培育项目(PX2020075);北京市医院管理中心“青苗”计划专项经费资助(QML20181903);北京市医院管理局临床医学发展专项“扬帆”计划(ZYLX201815)。

摘　　要：错误相关负波(error-related negativity,ERN)是个体错误行为反应后在额叶内侧区引起的事件相关电位成分,是反映行为监控功能的重要指标。本文回顾了强迫症ERN特征及其影响因素,并就ERN与强迫症临床症状的关系、治疗中的变化、潜在的神经基础和作为疾病内表型的可能性进行了论述,为理解强迫症的病理机制提供新的视角。The error-related negativity(ERN)is the medical frontal lobe component of event-related potentials caused by the individual incorrect response.It is an important indicator that reflects the function of performance monitoring.This article reviewed the characteristics and influencing factors of ERN in patients with obsessive-compulsive disorder(OCD),and also discussed the relationship between ERN and the clinical symptoms of OCD,the changes of ERN during treatment,the underlying neurological basis,and the possibility of ERN as an endophenotype of the disorder,thereby providing a new perspective on understanding the pathological mechanisms of OCD.

关 键 词：强迫性障碍 错误相关负波 行为监控 内表型 

分 类 号：R749.7[医药卫生—神经病学与精神病学]