泛素降解途径蛋白、碱性成纤维细胞生长因子及凋亡抑制蛋白在前列腺癌中的表达及与临床病理特征的相关性  

Expressions of Ubiquitin Degradation Pathway Protein,Basic Fibroblast Growth Factor and Apoptosis Inhibitor Protein in Prostate Cancer and Their Correlations with Clinicopathological Characteristics

作　　者：肖荣 于佳 杨元强 曾振华 XIAO Rong;YU Jia;YANG Yuan-qiang;ZENG Zhen-hua(Department of Urinary Surgery,Jiangbei People's Hospital Affiliated to Nantong University,Nanjing 210048,China;Department of Urinary Surgery,Affiliated Hospital of Xiangnan University,Chenzhou,Hunan 423000,China)

机构地区：[1]南通大学附属南京江北人民医院泌尿外科,南京210048 [2]湘南学院附属医院泌尿外科,湖南郴州423000

出　　处：《解放军医药杂志》2021年第12期24-29,共6页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：湖南省卫生健康委科研课题(20201281)。

摘　　要：目的分析泛素降解途径蛋白[S期激酶相关蛋白2(Skp2)、p27^(kip1)]及碱性成纤维细胞生长因子(b-FGF)、凋亡抑制蛋白(Survivin)在前列腺癌中的表达及与临床病理特征的关系。方法收集2015年1月—2017年1月保存的行手术切除的前列腺癌组织72例作为前列腺癌组,根据预后情况分为生存组49例和死亡组21例。同时选取同期良性前列腺增生标本60例作为良性组。收集所有患者临床资料,比较Skp2、p27^(kip1)、b-FGF、Survivin在前列腺癌组及良性组的表达情况,并分析其与临床病理参数的相关性。影响前列腺癌预后生存的危险因素采用多因素Logistic回归分析,绘制Kaplan-Meier生存曲线分析Skp2、p27^(kip1)、b-FGF、Survivin对患者预后生存的影响。结果前列腺癌组p27^(kip1)阳性表达率低于良性组,Skp2、b-FGF、Survivin阳性表达率高于良性组(P<0.01)。生存组p27^(kip1)阳性表达率高于死亡组,Skp2、b-FGF、Survivin阳性表达率低于生存组(P<0.05,P<0.01)。术前前列腺特异性抗原(PSA)水平>4μg/L、组织中低分化、TNM分期Ⅲ+Ⅳ期、Gleason评分≥7分、p27^(kip1)阴性表达及Skp2、b-FGF、Survivin阳性表达是影响前列腺癌患者预后生存的独立危险因素(P<0.05,P<0.01)。Skp2、b-FGF、Survivin阳性表达患者生存时间短于阴性组,p27^(kip1)阴性表达患者生存时间短于阳性组(P<0.01)。结论Skp2、p27^(kip1)、b-FGF、Survivin的异常表达与前列腺癌的侵袭与转移关系密切,可作为预测前列腺癌患者预后生存的分子标志物和肿瘤治疗的潜在靶点。Objective To analyze expressions of ubiquitin degradation pathway proteins[S phase kinase-associated protein 2(Skp2)and p27^(kip1),basic fibroblast growth factor(b-FGF)and apoptosis inhibitor protein(Survivin)in prostate cancer and their correlations with clinicopathological characteristics.Methods A total of 72 cases of resected prostate cancer tissues preserved between January 2015 and January 2017 were collected as prostate cancer group,and they were divided into survival subgroup(n=49)and death subgroup(n=21)according to prognoses.In the meantime,60 cases of benign prostatic hyperplasia samples were selected as benign group.Clinical data of all patients was collected,and expressions of Skp2,p27^(kip1),b-FGF and Survivin were compared between prostate cancer group and benign group,and their correlations with clinicopathological parameters were also analyzed.Multivariate Logistic regression analysis was used to analyze risk factors affecting the prognoses and survival of patients with prostate cancer.Kaplan Meier survival curve was drawn to analyze effects of Skp2,p27^(kip1),b-FGF and survivin on prognoses and survival of patients with prostate cancer.Results Compared with those in benign group,the positive expression rate of p27^(kip1) was significantly lower,while the positive expression rates of Skp2,b-FGF and Survivin were significantly higher in prostate cancer group(P<0.01).Compared with those in survival subgroup,the positive expression rate of p27^(kip1) was significantly higher,while the positive expression rates of Skp2,b-FGF and Survivin were significantly lower in survival subgroup(P<0.05,P<0.01).Preoperative level of prostate specific antigen(PSA)larger than 4μg/L,moderate-low differentiation,TNM stageⅢ+Ⅳ,Gleason score equal or more than 7 points,negative expression of p27^(kip1),and positive expressions of Skp2,b-FGF and Survivin were independent risk factors affecting prognoses and survival of patients with prostate cancer(P<0.05,P<0.01).The survival times of patients with positive expressio

关 键 词：前列腺肿瘤 前列腺特异抗原 S期激酶相关蛋白2 成纤维细胞生长因子2 Survivin 预后 

分 类 号：R737.25[医药卫生—肿瘤]