动脉优先入路胰十二指肠切除术+吉西他滨治疗胰腺癌的疗效评价  

Efficacy evaluation of pancreaticoduodenectomy with arterial priority approach combined with gemcitabine in the treatment of pancreatic cancer

作　　者：赵士鹏[1] ZHAO Shi-peng(Jianping County Hospital,Chaoyang 122400,China)

机构地区：[1]辽宁省朝阳市建平县医院,122400

出　　处：《中国现代药物应用》2021年第23期112-114,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 分析动脉优先入路胰十二指肠切除术+吉西他滨治疗胰腺癌的疗效。方法 40例胰腺癌患者作为研究对象,以抽签的形式分为对照组和实验组,每组20例。对照组选择传统胰十二指肠切除术+吉西他滨治疗,实验组选择动脉优先入路胰十二指肠切除术+吉西他滨治疗。比较两组患者治疗前后的卡氏功能状态量表(KPS)评分、肿瘤标记物[糖类抗原199(CA199)、糖类抗原125(CA125)]及癌胚抗原(CEA)水平,治疗效果。结果 治疗后,实验组患者的KPS评分(75.05±7.15)分明显高于对照组的(63.37±7.65)分, CA199(33.36±2.15)U/ml、CA125(39.98±3.17)U/ml、CEA(16.23±1.42)μg/L明显低于对照组的(39.07±1.87)U/ml、(45.56±3.60)U/ml、(20.01±1.60)μg/L,差异有统计学意义(P<0.05)。实验组总有效率80.00%高于对照组的50.00%,差异有统计学意义(P<0.05)。结论 在胰腺癌患者的临床治疗中,动脉优先入路胰十二指肠切除术+吉西他滨治疗效果良好,更有利于改善患者的健康状况。Objective To analyze the efficacy of pancreaticoduodenectomy with arterial priority approach combined with gemcitabine in the treatment of pancreatic cancer.Methods A total of 40 patients with pancreatic cancer were taken as study subjects,and they were divided into the control group and the experimental group by lottery method,with 20 cases in each group.The control group was treated with traditional pancreaticoduodenectomy and gemcitabine treatment,and the experimental group was treated with pancreaticoduodenectomy with arterial priority approach in combination with gemcitabine.Both groups were compared in terms of Karnofsky performance status(KPS)score,tumor markers[carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125)]and carcinoembryonic antigen(CEA)levels before and after treatment,and the therapeutic effect.Results After treatment,the KPS score(75.05±7.15)points of the experimental group was significantly higher than(63.37±7.65)points of the control group,and the CA199(33.36±2.15)U/ml,CA125(39.98±3.17)U/ml,CEA(16.23±1.42)μg/L were significantly lower than(39.07±1.87)U/ml,(45.56±3.60)U/ml,(20.01±1.60)μg/L of the control group.All the differences were statistically significant(P<0.05).The total effective rate 80.00%in the experimental group was higher than 50.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion In the clinical treatment of patients with pancreatic cancer,pancreaticoduodenectomy with arterial priority approach in combination with gemcitabine is effective and more beneficial to improve the health status of patients.

关 键 词：胰腺癌 动脉优先入路胰十二指肠切除术 吉西他滨 治疗效果 健康状况 

分 类 号：R735.9[医药卫生—肿瘤]