齐拉西酮联合舍曲林治疗强迫症患者的效果  

Effects of Ziprasidone combined with Sertraline in treatment of patients with obsessive-compulsive disorder

作　　者：崔玉 CUI Yu(Drug Management Department of Yanbian Shehui Brain Health Hospital(Yanbian Rongjun Hospital),Yanji 133000 Jilin,China)

机构地区：[1]延边社会脑康医院(延边荣军医院)药品管理科,吉林延吉133000

出　　处：《中国民康医学》2021年第22期67-69,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察齐拉西酮联合舍曲林治疗强迫症患者的效果。方法:选取86例强迫症患者为研究对象,采用随机数字表法分为观察组和对照组各43例。对照组采用舍曲林治疗,观察组在对照组基础上联合齐拉西酮治疗,比较两组治疗前后耶鲁-布朗强迫量表(Y-BOCS)评分、临床疗效、不良反应发生率和不良反应量表(TESS)评分。结果:观察组Y-BOCS评分低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为93.02%,高于对照组的74.42%,差异有统计学意义(P<0.05);两组不良反应发生率和TESS评分比较,差异均无统计学意义(P>0.05)。结论:齐拉西酮联合舍曲林治疗强迫症患者可提高治疗总有效率,降低Y-BOCS评分,效果优于单纯舍曲林治疗,且安全性较好。Objective:To observe effects of Ziprasidone combined with Sertraline in treatment of patients with obsessive-compulsive disorder.Methods:86 patients with obsessive-compulsive disorder were selected as the research objects,and were divided into observation group and control group by using the random number table method,43 cases in each group.The control group was treated with Sertraline,while the observation group was treated with Ziprasidone on the basis of that of the control group.The severity of obsessive-compulsive symptoms[Yale-Brown obsessivecompulsive scale(Y-BOCS)]score,the clinical efficacy,the incidence of adverse reactions,and the severity of adverse reactions[treatment emergent symptom scale(TESS)]score were compared between the two groups before and after the treatment.Results:The Y-BOCS score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was 93.02%,which was higher than 74.42%in the control group,and the difference was statistically significant(P<0.05).However,there were no statistically significant differences in the incidence of adverse reactions and the TESS scores between the two groups(P>0.05).Conclusions:Ziprasidone combined with Sertraline in the treatment of the patients with obsessive-compulsive disorder can improve the total effective rate of treatment and reduce the Y-BOCS score.Moreover,its effects are better than single Sertraline treatment with higher safety.

关 键 词：强迫症 齐拉西酮 舍曲林 耶鲁-布朗强迫量表 不良反应量表 

分 类 号：R749[医药卫生—神经病学与精神病学]