帕金森病病人血清白细胞介素-6、白细胞介素-1β及肿瘤坏死因子α水平变化及其临床意义  

Changes and clinical significance of serum interleukin-6,interleukin-1βand tumor necrosis factorαin patients with Parkinson's disease

作　　者：温雅[1] 王珊[1] 刘琦[1] 王梁[1] 姜虹[1] 王惠娟[1] WEN Ya;WANG Shan;LIU Qi;WANG Liang;JIANG Hong;WANG Huijuan(Department of Neurology,Second Hospital of Hebei Medical University,Shijiazhuang,Hebei 050000,China)

机构地区：[1]河北医科大学第二医院神经内科,河北石家庄050000

出　　处：《安徽医药》2022年第1期54-57,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的分析帕金森病病人血清白细胞介素(IL)-6、IL-1β及肿瘤坏死因子α(TNF-α)水平变化及其临床意义。方法2015年6月至2019年6月河北医科大学第二医院诊治帕金森病94例作为观察组、健康体检者50例作为对照组,采用ELISA法检测两组受试者血清IL-6、IL-1β及TNF-α含量,分析其在帕金森病病人中的临床意义。结果观察组病人血清IL-6、IL-1β及TNF-α水平明显高于对照组[(18.53±2.14)pg/mL比(3.26±0.52)pg/mL,(183.26±15.40)pg/mL比.(21.57±3.55)pg/mL,(376.19±32.07)pg/mL比(207.11±17.21)pg/mL,P<0.05];存在认知功能障碍的帕金森病病人IL-6、IL-1β及TNF-α及MoCA评分明显高于认知功能正常者[(21.37±2.73)pg/mL比(17.14±2.06)pg/mL,(196.41±17.85)pg/mL比(175.23±14.11)pg/mL,(408.52±35.49)pg/mL比(361.24±30.55)pg/mL,(28.47±2.87)分比(21.32±1.45)分,P<0.05];但不同Hoehn Yahr分级情况帕金森病病人IL-6、IL-1β及TNF-α水平的比较,差异无统计学意义(P>0.05);帕金森病病人IL-6、IL-1β及TNF-α水平分别与MoCA评分呈正相关(P<0.05),而与Hoehn Yahr分级无明显相关性(P>0.05)。结论血清IL-6、IL-1β及TNF-α水平在帕金森病病人中呈高水平,与病人认知功能密切相关,但不能反映病人疾病严重程度。Objective To analyze the changes and clinical significance of serum interleukin(IL)-6,IL-1βand tumor necrosis factorα(TNF-α)in patients with Parkinson's disease(PD).Methods A total of 94 patients with PD treated in Second Hospital of Hebei Medical University from June 2015 to June 2019 were enrolled as observation group,while other 50 healthy controls were enrolled as control group.The levels of serum IL-6,IL-1βand TNF-αin both groups were detected by ELISA.Their clinical significance in PD patients was analyzed.Results The levels of serum IL-6,IL-1βand TNF-αin the observation group were significantly higher than those in the control group[(18.53±2.14)pg/mL vs.(3.26±0.52)pg/mL,(183.26±15.40)pg/mL vs.(21.57±3.55)pg/mL,(376.19±32.07)pg/mL vs.(207.11±17.21)pg/mL,P<0.05].The levels of IL-6,IL-1βand TNF-α,and MoCA score in PD patients with cognitive dysfunction were significantly higher than those with normal cognitive function[(21.37±2.73)pg/mL vs.(17.14±2.06)pg/mL,(196.41±17.85)pg/mL vs.(175.23±14.11)pg/mL,(408.52±35.49)pg/mL vs.(361.24±30.55)pg/mL,(28.47±2.87)points vs.(21.32±1.45)points,P<0.05].There was no significant difference in levels of serum IL-6,IL-1βand TNF-αamong PD patients with different Hoehn Yahr grading(P>0.05).The levels of IL-6,IL-1βand TNF-αin PD patients were positively correlated with MoCA score(P<0.05),while not significantly correlated with Hoehn Yahr grading(P>0.05).Conclusion The levels of serum IL-6,IL-1βand TNF-αare high in PD patients,which are closely related to cognitive function.However,they cannot reflect disease severity.

关 键 词：帕金森病 白细胞介素-6 白细胞介素-1Β 肿瘤坏死因子Α 认知功能 

分 类 号：R742.5[医药卫生—神经病学与精神病学]