阿尔茨海默病与原发性骨质疏松症相关性研究进展  

Research progress of the correlation between Alzheimer's disease and primary osteoporosis

作　　者：王江波[1] 张冠群[1] WANG Jiang-bo;ZHANG Guan-qun(Xuzhou Central Hospital,The Xuzhou School of Clinical Medicine Of Nanjing Medical University,Xuzhou,Jiangsu 221009,China)

机构地区：[1]徐州市中心医院,南京医科大学徐州临床医学院神经内科,江苏徐州221000

出　　处：《阿尔茨海默病及相关病杂志》2021年第3期245-248,共4页Chinese Journal of Alzheimer's Disease and Related Disorders

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)和骨质疏松症(osteoporosis,OP)是老年人群中最常见的退行性疾病。AD和OP表面上看是两种截然不同的疾病,但越来越多的研究表明两者存在一些共有的致病因素、发病机制和信号通路。一些体内外的研究支持了这一观点。AD患者脑内淀粉样蛋白过多,病变可延伸至外周器官,引起骨骼淀粉样沉积,这将增强核因子NF-κB受体活化体配体信号,导致破骨细胞活性增强。OP患者可能缺乏维生素D或维生素D结合蛋白水平较低,维生素D结合蛋白可以防止淀粉样蛋白聚集,从而将维生素D缺乏与AD和OP联系起来。Wnt信号拮抗剂DKK1可能是连接AD和OP的一个共同风险分子。The Alzheimer's disease(Alzheimer's disease,AD)and osteoporosis(osteoporosis,OP)is the most common degenerative disease in the elderly population.AD and osteoporosis appear to be two distinct diseases,but more and more studies have shown that they share some common pathogenic factors,pathogenesis and signaling pathways.Several studies in vivo and in vitro support this idea.In patients with AD,there is too much amyloid protein in the brain,which can extend to peripheral organs and cause skeletal amyloid deposition,which will enhance the ligand signal of nuclear factor NF-κB receptor activator and lead to enhanced osteoclast activity.People with osteoporosis may be deficient in vitamin D or have low levels of vitamin D-binding protein,which prevents amyloid aggregation,thus linking vitamin D deficiency to AD and osteoporosis.Wnt signal antagonist DKK1 might be a potential common risk molecule connecting both AD and osteoporosis.

关 键 词：阿尔茨海默病 骨质疏松症 淀粉样蛋白 维生素D结合蛋白 WNT信号 

分 类 号：R741[医药卫生—神经病学与精神病学]