Multi-intervention integrated deworming strategy for sustained control of soil-transmitted helminths infections: a case study in Jiangsu Province, China  

作　　者：Fan‑Zhen Mao Yu‑Ying Chen Xiang‑Zhen Xu Bi‑Xian Ni Xiao‑Lin Jin Yang Dai Jun Cao 

机构地区：[1]National Health Commission(NHC)Key Laboratory of Parasitic Disease Con‑trol and Prevention,Jiangsu Provincial Key Laboratory On Parasite and Vector Control Technology,Jiangsu Institute of Parasitic Diseases,Wuxi City,Jiangsu Province 214064,People’s Republic of China [2]Center for Global Health,Nanjing Medical University,Nanjing City,Jiangsu Province 211166,People’s Republic of China [3]Public Health Research Center,Jiangnan University,Wuxi City,Jiangsu Province 214064,People’s Republic of China

出　　处：《Infectious Diseases of Poverty》2021年第5期73-82,共10页贫困所致传染病（英文）

基　　金：supported by the National Key R&D Program of China(2020YFC1200100);the Jiangsu Provincial Department of Science and Technology(BM2018020);the Jiangsu Provincial Project of Invigorating Health Care through Science,Technology,and Education(ZDXKA2016016)。

摘　　要：Background:Soil-transmitted helminths(STH)infections still present a global health problem.Mass drug adminis‑tration(MDA)is a widely applied strategy to reduce morbidity and mortality caused by STH.Yet,this approach has some shortcomings.In this study,we analyzed the impact of a multi-intervention integrated deworming approach including MDA,health education(HE),and environmental sanitation improvements(ESI)for sustained STH control in Jiangsu Province of China that was applied from 1989 to 2019.Methods:Data,including infection rate of STH,medications used,coverage of the medication,non-hazardous lavatory rate,and household piped-water access rate in rural areas,and actions related to HE and ESI were collected(from archives)and analyzed in this retrospective descriptive study.Pearson’s correlation analysis was applied to test correlations.Results:There was a dramatic decline in the infection rate of STH from 1989(59.32%)to 2019(0.12%).From 1995 to 1999,MDA and HE were recommended in rural areas.A negative correlation was observed between infection rate and medication from 1994 to 1998(r=-0.882,P=0.048).From 2000 to 2005,targeted MDA was given to high-risk populations with HE continuously promoting good sanitation behaviors.From 2006 to 2014,targeted MDA+HE and ESI were used to consolidate the control efect.ESI was strengthened from 2006,and a negative correlation was observed between the coverage rate of the non-hazardous lavatory and the infection rate from 2006 to 2019(r=-0.95,P<0.001).The targeted MDA was interrupted in 2015,while continuous eforts like HE and ESI contributed in sustaining STH control.Conclusions:Multi-intervention integrated deworming strategy contributes to the reduction of STH infections.This approach is a valuable example of how diferent interventions can be integrated to promote durable STH control.

关 键 词：Soil-transmitted helminths Multi-intervention CONTROL STRATEGY China 

分 类 号：R53[医药卫生—内科学] R181.3[医药卫生—临床医学]