无功能垂体腺瘤的垂体相关转录因子表达与临床特征分析  

Expression of pituitary-related transcription factors in non-functioning pituitary adenomas and its clinical significance

作　　者：唐晓爽 张晓青 尹华春 郑新 李松 杨辉 TANG Xiao-shuang;ZHANG Xiao-qing;YIN Hua-chun;ZHENG Xin;LI Song;YANG Hui(Department of Neurosurgery,Second Affiliated Hospital of Army Medical University,PLA,Chongqing 400037,China)

机构地区：[1]陆军军医大学第二附属医院神经外科,重庆400037

出　　处：《中国临床神经外科杂志》2021年第12期907-911,共5页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨垂体相关转录因子在无功能垂体腺瘤中的表达情况及其临床意义。方法收集2013~2019年手术切除的无功能垂体腺瘤组织151例,采用组织芯片技术检测5个垂体相关转录因子(Pit-1、SF-1、GATA2、Tpit、ERα)的表达。结果5个转录因子均阴性36例,Pit-1阳性91例,SF-1阳性11例,GATA2阳性9例,ERα阳性4例;生长激素(GH)细胞腺瘤53例,多激素细胞腺瘤42例,零细胞腺瘤36例,促性腺激素(GnH)细胞腺瘤11例,促甲状腺激素(TSH)细胞腺瘤9例,各类无功能垂体腺瘤病人的年龄和Ki-67指数无统计学差异(P>0.05),TSH细胞腺瘤体积最小、侵袭性比例最低(P<0.05),多激素细胞腺瘤、GnH细胞腺瘤和零细胞腺瘤体积较大(P<0.05),零细胞腺瘤P53阳性率最低(P<0.05)。5个转录因子阳性表达以40~59岁病人多见(P<0.05);Tpit阳性表达以男性多见(P<0.05),其余4个转录因子以女性多见(P<0.05)。Pit-1阳性病人血清GH、TSH水平明显增高(P<0.01),ERa阳性病人血清泌乳素水平明显增高(P<0.05),GATA2阳性病人血清TSH水平明显增高(P<0.01),血清促肾上腺皮质激素水平与5个转录因子表达水平无明显关系(P>0.05)。结论垂体相关转录因子可以为临床诊断无功能垂体腺瘤提供新依据,而且其阳性表达与无功能垂体腺瘤病人的临床特征有密切联系。Objective To explore the expression of pituitary-related transcription factors in tumor tissues and its relationship with the clinical features of patients with non-functioning pituitary adenoma.Methods The expressions of five pituitary-related transcription factors(Pit-1,SF-1,GATA2,Tpit,ERα)were detected by tissue microarray technique in non-functional adenoma tissues obtained from 151 patients with non-functional adenoma who underwent microsurgery from 2013 to 2019.Results Of 151 patients,36 patients were negative for 5 transcription factors,91 positive for Pit-1,11 positive for SF-1,9 positive for GATA2,and 4 positive for ERα;53 patients were growth hormone(GH)cell adenomas,42 multihormonal cell adenomas,36 adenomas without pituitary cell differentiation markers,11 gonadotropin(GnH)cell adenomas,and 9 thyroid stimulating hormone(TSH)cell adenomas.There was no significant differences in the age and Ki-67 index among various non-functioning pituitary adenomas(P>0.05).The tumor volume was smallest and the aggressive rate was lowest in TSH cell adenomas(P<0.05).The tumor volume was larger in multihormonal cell adenomas,GnH cell adenomas and adenomas without pituitary cell differentiation markers(P<0.05).The P53 positive rate was lowest in the adenomas without pituitary cell differentiation markers(P<0.05).The positive expression of 5 transcription factors was more common in patients aged 40~59 years(P<0.05);the positive expression of Tpit was more common in male patients(P<0.05),and the other 4 pituitary-related transcription factors were more common in female patients(P<0.05).The serum GH and TSH levels of Pit-1 positive patients were significantly increased(P<0.01),the serum prolactin levels of ERa positive patients were significantly increased(P<0.05),the serum TSH levels of GATA2-positive patients were significantly increased(P<0.01).Conclusions The pituitary-related transcription factors can provide a new basis for clinical diagnosis of non-functioning pituitary adenomas.The expression of pituitary-related

关 键 词：无功能垂体腺瘤 垂体相关垂体相关转录因子 基因表达 临床特征 

分 类 号：R739.41[医药卫生—肿瘤] Q786[医药卫生—临床医学]