胶质瘤CMTM 1、CMTM 6的表达及其临床意义  

Expression of CMTM 1 and CMTM 6 in human glioma tissues and its clinical significance

作　　者：黄晓东[1] 严立冬 杨明环 李丹[2] 杨博文 张力[1] 黄宽明[1] 鲁军体[1] HUANG Xiao-dong;YAN Li-dong;YANG Ming-huan;LI Dan;YANG Bo-wen;ZHANG Li;HUANG Kuan-ming;LU Jun-ti(Department of Neurosurgery,Shiyan Taihe Hospital,Affiliated Hospital of Hubei Medical College,Shiyan 442000,China;Department of Pathology,Shiyan Taihe Hospital,Affiliated Hospital of Hubei Medical College,Shiyan 442000,China)

机构地区：[1]十堰市太和医院(湖北医药学院附属太和医院)神经外科,湖北442000 [2]十堰市太和医院(湖北医药学院附属太和医院)病理科,湖北442000

出　　处：《中国临床神经外科杂志》2021年第12期938-940,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨趋化素样因子超家族(CMTM)1、CMTM6表达水平与胶质瘤病人预后的关系。方法收集2016年1月~2019年6月手术切除的胶质瘤组织96例和颅脑损伤内减压术中切除的非肿瘤脑组织40例(对照组),采用免疫组织化学染色检测CMTM1、CMTM6的表达水平。随访24个月,记录胶质瘤病人生存情况。结果胶质瘤组CMTM1和CMTM6高表达率[分别为64.58%(62/96)、67.71%(65/96)]明显高于对照组[分别为25%(10/40)、20.00%(8/40);P<0.01]。胶质瘤组织CMTM1与CMTM6表达水平呈正相关(r=0.837,P<0.001)。本文96例随访2年,死亡37例,生存59例。多因素Cox比例回归风险模型分析显示,CMTM1过表达、CMTM6高表达是胶质瘤预后不良的独立危险因素(P<0.05)。生存曲线分析显示,CMTM1、CMTM6高表达组2年累积生存率(分别为50.15%、52.05%)明显低于表达组(分别为79.85%、84.95%;P<0.05)。结论胶质瘤组织CMTM 1、CMTM 6呈高表达,与病人的不良生存预后有关。Objective To explore the relationship between the expression levels of CKLF-like MARVEL transmembrane domaincontaining family(CMTM)1 and CMTM6 and the prognosis of glioma patients.Methods The expression levels of CMTM1 and CMTM6 were detected using immunohistochemical staining in glioma tissues obtained from 96 glioma patients(glioma group)who underwent microsurgery and in non-tumor cerebral tissues obtained from 40 patients with traumatic brain injury(control group)who underwent decompression from January 2016 to June 2019.The glioma pstients were followed up for 2 years.Results The high expression rate of CMTM1 and CMTM6 in the glioma group[64.58%(62/96)and 67.71%(65/96),respectively]was significantly higher than those[25%(10/40)and 20.00%(8/40),respectively]in the control group(P<0.05).The expression level of CMTM1 in glioma tissues were positively correlated with CMTM6 expression level(r=0.837,P<0.001).Of 96 glioma patients,37 patients died and 59 survived 2 years after the operation.Multivariate Cox proportional regression risk model analysis showed that overexpression of CMTM1 and overexpression of CMTM6 were independent risk factors for poor prognosis of glioma patients(P<0.05).Survival curve analysis showed that the 2-year cumulative survival rates of the CMTM1-and CMTM6-high expression groups(50.15%and 52.05%,respectively)were significantly lower than those(79.85%and 84.95%,respectively)of the CMTM1-and CMTM6-low expression groups(P<0.05).Conclusions CMTM 1 and CMTM 6 are highly expressed in glioma tissues and are related to the poor survival prognosis of glioma patients.

关 键 词：胶质瘤 趋化素样因子超家族 CMTM1 CMTM6 预后 

分 类 号：R739.41[医药卫生—肿瘤] Q78[医药卫生—临床医学]