感染与阿尔茨海默病相关性的研究进展  

Research advances in the association between microbial infection and Alzheimer’s disease

作　　者：陈瑶鑫 傅勤慧[1] 裴建[1] CHEN Yao-Xin;FU Qin-Hui;PEI Jian(Longhua Hospital,University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院针灸科,上海200032

出　　处：《国际神经病学神经外科学杂志》2021年第5期495-500,共6页Journal of International Neurology and Neurosurgery

基　　金：上海市科学技术委员会科研计划重点项目(18401970500,16401970300);上海市卫计委重点项目[ZY(2018-2020)CCCX1106]。

摘　　要：阿尔茨海默病(AD)发生的机制尚不清晰。长期以来,有学者一直怀疑病原体感染可能在阿尔茨海默病中起关键作用。病原体可能通过直接感染中枢神经系统或者间接感染其他系统,激活免疫系统,促进淀粉样蛋白的形成,损害神经元功能,导致阿尔茨海默病的发生。本综述的目的在于阐明感染与阿尔茨海默病的病理联系,回顾感染与阿尔茨海默病相关的证据。The pathogenesis of Alzheimer’s disease(AD)remains elusive.Pathogen infection has long been proposed as a causative factor of AD.By directly infecting the central nervous system or indirectly affecting other systems,pathogens may activate the immune system,promote amyloid formation,and impair neuronal function,leading to the development of AD.The purpose of this article is to elucidate the pathological connection between infection and AD and to review the available evidence.

关 键 词：阿尔茨海默病 免疫系统 微生物 感染 

分 类 号：R741[医药卫生—神经病学与精神病学]