外泌体在肝纤维化发生发展及诊治中的作用  

Role of exosomes in the development,progression,diagnosis,and treatment of liver fibrosis

作　　者：罗业浩 陈秋霞 吕挺 区佩琪 曹知勇 段雪琳[1] LUO Yehao;CHEN Qiuxia;LYU Ting;OU Peiqi;CAO Zhiyong;DUAN Xuelin(Key Laboratory of Zhuang Medicine Prescriptions Basis and Application Research,Guangxi University of Chinese Medicine,Nanning 530200,China;School of Medicine,Hubei Minzu University,Enshi,Hubei 445000,China)

机构地区：[1]广西中医药大学,壮医方药基础与应用研究重点实验室,南宁530200 [2]湖北民族大学医学部,湖北恩施445000

出　　处：《临床肝胆病杂志》2021年第12期2919-2923,共5页Journal of Clinical Hepatology

基　　金：校级一流学科建设开放课题项目(2019XK040)。

摘　　要：越来越多研究证实外泌体与肝纤维化的关系十分密切,外泌体参与细胞因子分泌、巨噬细胞活化、细胞外基质重塑及肝星状细胞活化从而介导肝纤维化的进程。总结了肝纤维化的逆转通过减少外泌体参与的促炎和纤维化细胞因子,减少细胞外基质蛋白的产生,增加胶原酶的活性,最后导致活化的肌成纤维细胞消失。认为外泌体在治疗肝纤维化中具有重要价值,是潜在的诊断和治疗的标志物,在日后的研究中,可以提高外泌体的提取技术及治疗定量的标准化制定。An increasing number of studies have demonstrated that exosomes are closely associated with liver fibrosis and mediate the process of liver fibrosis by participating in cytokine secretion,macrophage activation,extracellular matrix remodeling,and hepatic stellate cell activation.This article summarizes that the resolution of liver fibrosis requires the reduction of pro-inflammatory and fibrotic cytokines,the reduction of extracellular matrix protein production,the increase of collagenase activity,and finally the loss of activated myofibroblasts.It is believed that exosomes play an important role in the treatment of liver fibrosis and are potential markers for diagnosis and treatment,and in future studies,it is necessary to improve exosome extraction techniques and standardization of treatment quantification.

关 键 词：肝硬化 外泌体 病理过程 诊断 治疗学 

分 类 号：R575.2[医药卫生—消化系统]