外泌体及其携带的microRNA与脑卒中的研究进展  

Research progress in exosomes,miRNA carried by exosome,and stroke

作　　者：王孟杰 冯嵩[2] 马文渊 陈超 靳峰[2] Wang Mengjie;Feng Song;Ma Wenyuan;Chen Chao;Jin Feng(Clinical College of Jining Medical University,Jining 272000,China;Department of Neurosurgery,Affiliated Hospital of Jining Medical University,Jining 272000,China)

机构地区：[1]济宁医学院临床医学院,山东济宁272000 [2]济宁医学院附属医院神经外科,山东济宁272000

出　　处：《中华脑血管病杂志（电子版）》2021年第6期418-421,共4页Chinese Journal of Cerebrovascular Diseases(Electronic Edition)

基　　金：山东省医药卫生科技发展计划项目(2014WS0518);济宁市科技重点研发计划(2018SMNS005);济宁医学院教师科研扶持基金(JYFC2018FKJ100)。

摘　　要：外泌体是一种可以由不同种类细胞分泌的特殊囊泡,能携带包括microRNA和蛋白质等生物分子在内的多种物质,参与细胞间的信号交流。脑卒中是一种复杂的脑血管疾病,特点是高致死率和高致残率。目前缺少更加特异的生物学标志物评估脑卒中造成的损伤程度和病情进展程度,同时治疗脑卒中的药物存在疗效不理想、副作用大等缺陷,而外泌体在脑卒中的发生和神经修复过程中发挥着作用,具有潜在的诊断、病情监测及治疗价值。本文就外泌体及其所携带的microRNA在缺血性脑卒中和出血性脑卒中的作用进行综述,以期为脑卒中的诊断、病情监测及治疗提供帮助。Exosomes are special vesicles secreted by different kinds of cells,which can carry a variety of substances including microRNA(miRNA)and proteins,participating in intercellular signal communication.Stroke is a complex cerebrovascular disease,characterized by high mortality and high disability.Currently,there is a lack of specific biomarkers to assess the severity of damage and progression caused by stroke.At the same time,medicine treatment for stroke is not satisfying,with considerable side effects.Exosomes play an important role in stroke and afterwards neural repair,showing potential diagnostic,monitoring and therapeutic application.Here,we review the role of exosomes and exosome-derived miRNA in ischemic stroke and hemorrhagic stroke in order to enlighten the diagnosis,monitoring and treatment of stroke.

关 键 词：外泌体 MICRORNA 脑卒中 神经保护 治疗载体 

分 类 号：R743.3[医药卫生—神经病学与精神病学]