加味益气方对子宫内膜癌术后患者免疫球蛋白M、免疫球蛋白G、免疫球蛋白A、癌胚抗原、糖类抗原125、糖类抗原199及血清人附睾蛋白4水平的影响  

Effect of Jiawei Yiqi Recipe on the Levels of IgM,IgG,IgA,CEA,CA125,CA199 and HE4 in Postoperative Endometrial Cancer Patients

作　　者：何琳[1] 杨志峰[1] 袁鸿[1] 焦颖 谢占清[1] HE Lin;YANG Zhi-feng;YUAN Hong;JIAO Ying;XIE Zhan-qing(Department of Gynecology,Baoding Second Hospital,Baoding Hebei 071051)

机构地区：[1]保定市第二医院妇科,河北保定071051

出　　处：《世界中西医结合杂志》2021年第10期1891-1895,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省保定市科技计划项目(1951ZF023)。

摘　　要：目的观察加味益气方对子宫内膜癌术后患者免疫球蛋白M(Immunoglobulin M,IgM)、免疫球蛋白G(Immunoglobulin G,IgG)、免疫球蛋白A(Immunoglobulin A,IgA)、癌胚抗原(Carcinoembryonic antigen,CEA)、糖类抗原125(Carbohydrate antigen 125,CA125)、糖类抗原199(Carbohydrate antigen199,CA199)及血清人附睾蛋白4(Human Epididymis Protein4,HE4)水平的影响。方法选取2020年1月—2021年4月期间于保定市第二医院妇科收治的116例子宫内膜癌术后患者,按随机数字表法分为研究组和对照组,每组各58例。其中对照组给予常规西药化疗方案治疗,研究组在对照组治疗的基础上给予加味益气方治疗。治疗3周后,分别比较两组患者治疗前后中医证候积分、CEA、CA125、CA199及HE4水平及IgM、IgG、IgA水平,并观察临床疗效及不良反应发生情况。结果治疗后两组患者赤白带下、阴道出血量大、臭秽难闻、气短声低、体倦乏力、少气懒言、头晕目眩、自汗评分均较治疗前降低,差异有统计学意义(P<0.05);且研究组治疗后赤白带下、阴道出血量大、臭秽难闻、气短声低、体倦乏力、少气懒言、头晕目眩、自汗评分均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后研究组总有效率96.55%(56/58)明显高于对照组82.76%(48/58),两组比较,差异有统计学意义(P<0.05)。治疗后两组患者CEA、CA125、CA199、HE4水平均较治疗前降低,差异有统计学意义(P<0.05);且研究组治疗后CEA、CA125、CA199、HE4水平均较对照组降低,差异有统计学意义(P<0.05)。治疗后两组患者IgM、IgG、IgA水平均较治疗前升高,差异有统计学意义(P<0.05);且研究组治疗后IgM、IgG、IgA水平均较对照组明显升高,差异有统计学意义(P<0.05)。治疗期间,对照组不良反应发生率为12.07%(7/58),研究组不良反应发生率为1.72%(1/58),两组比较,差异有统计学意义(P<0.05)。结论加味益气方能够有效降低子宫内膜癌术后患�Objective To explore the effects of Jiawei Yiqi Recipe on immunoglobulin M(Immunoglobulin M,IgM),immunoglobulin G(Immunoglobulin G,IgG),immunoglobulin A(Immunoglobulin A,IgA),carcinoembryonic antigen(Carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199)and serum human epididymis protein 4(Human Epididymis Protein 4,HE4)levels.Methods 116 postoperative endometrial cancer patients who were admitted to the Department of Gynecology of Baoding Second Hospital from January 2020 to April 2021 were selected as the research objects.According to the random number table,they were divided into a study group and a control group with 58 cases each.The control group was treated with conventional western medicine chemotherapy,and the study group was treated with Jiawei Yiqi Recipe on the basis of the treatment of the control group.After 3 weeks of treatment,the TCM syndrome scores,CEA,CA125,CA199 and HE4 levels,and Ig M,IgG,and IgA levels were compared between the two groups of patients before and after treatment,and the clinical efficacy was observed.Results After treatment,the two groups of patients with red and white vaginal bleeding,heavy vaginal bleeding,unpleasant smell,shortness of breath,fatigue,lack of breath,dizziness,and spontaneous sweating scores were all lower than before treatment,and the differences were statistically significant.(P<0.05);After treatment,the scores of red leucorrhea,vaginal bleeding,bad smell,shortness of breath,low voice,fatigue,lack of breath,dizziness,and spontaneous sweating in the study group were significantly lower than those in the control group,The difference was statistically significant(P<0.05).After treatment,the total effective rate of 96.55%(56/58)in the study group was significantly higher than 82.76%(48/58)in the control group.The difference between the two groups was statistically significant(P<0.05).After treatment,the levels of CEA,CA125,CA199,and HE4 in the two groups of patients were lower than before treatment,and the difference was st

关 键 词：加味益气方 子宫内膜癌术后 免疫功能 

分 类 号：R737.33[医药卫生—肿瘤]